Goshen E, Livne A, Krupp M, Hammarström L, Dighiero G, Slor H, Shoenfeld Y
Department of Medicine D, Soroko Medical Center, Faculty of Health Science, Ben-Gurion University, Beer Sheva, Israel.
J Autoimmun. 1989 Feb;2(1):51-60. doi: 10.1016/0896-8411(89)90107-8.
The sera of 49 healthy IgA-deficient (SIgAD) subjects were evaluated for the presence of autoantibodies directed against 10 different nuclear and cytoskeletal antigens, as well as for the presence of the common lupus anti-DNA idiotype (16/6 Id). Twenty-nine sera were from IgG subclass-deficient subjects (4 = IgG2, 25 = IgG3), and 25 from normal healthy subjects, used as controls. The incidence of antinuclear but not anti-cytoskeletal antibodies were found to be significantly greater in the SIgAD group, as compared to the IgG-deficient subjects and the normal controls. Overall, 39% of SIgAD sera demonstrated polyreactivity, namely reactivity against more than one nuclear antigen. The incidence of specific antibody detection ranged from 37% against cardiolipin to 12% against RNP in the IgA-deficient group, albeit not with statistical significance in all cases when compared to the control group. Isotype evaluation of the antinuclear and related antibodies in the SIgAD group showed a greater tendency towards IgG. This increased incidence of autoantibody production in SIgAD may preceed the development of an overt autoimmune disease in the future.
对49名健康的IgA缺乏症（SIgAD）患者的血清进行了评估，以检测针对10种不同核抗原和细胞骨架抗原的自身抗体，以及常见的狼疮抗DNA独特型（16/6 Id）。29份血清来自IgG亚类缺乏症患者（4份为IgG2缺乏，25份为IgG3缺乏），25份来自正常健康受试者，作为对照。与IgG缺乏症患者和正常对照组相比，SIgAD组中抗核抗体而非抗细胞骨架抗体的发生率显著更高。总体而言，39%的SIgAD血清表现出多反应性，即对一种以上核抗原具有反应性。在IgA缺乏症组中，特异性抗体检测的发生率从抗心磷脂的37%到抗RNP的12%不等，尽管与对照组相比，并非所有情况都具有统计学意义。对SIgAD组中的抗核抗体及相关抗体进行的亚型评估显示，其更倾向于IgG。SIgAD中自身抗体产生的这种增加的发生率可能在未来明显的自身免疫性疾病发生之前出现。
