端粒（TTAGGG）n序列在鸡（家鸡）染色体中的定位。

Localization of the telomeric (TTAGGG)n sequence in chicken (Gallus domesticus) chromosomes.

作者信息

Nanda I, Schmid M

机构信息

Department of Human Genetics, University of Würzburg, FRG.

出版信息

Cytogenet Cell Genet. 1994;65(3):190-3. doi: 10.1159/000133630.

DOI:10.1159/000133630

PMID:8222759

Abstract

The distribution of the highly conserved eukaryotic telomeric (TTAGGG)n sequence was investigated in chicken metaphase chromosomes using the FISH technique. Besides the expected telomeric locations, interstitial as well as centromeric locations of the (TTAGGG)n repeat were observed on several macrochromosomes. The microchromosomes display three discrete patterns of labeling with this repeat. The significance of this extreme-different distribution of the telomeric related sequence in chicken chromosomes may lie in pointing to structural events that might have occurred during the process of karyotype evolution.

摘要

利用荧光原位杂交（FISH）技术，研究了高度保守的真核生物端粒（TTAGGG）n序列在鸡中期染色体中的分布情况。除了预期的端粒位置外，在几条常染色体上还观察到了（TTAGGG）n重复序列的间质位置以及着丝粒位置。微染色体显示出这种重复序列的三种不同的标记模式。鸡染色体中端粒相关序列这种极其不同的分布的意义可能在于指出在核型进化过程中可能发生的结构事件。