Rafatullah S, Tariq M, Mossa J S, al-Yahya M A, al-Said M S, Ageel A M
Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Drugs Exp Clin Res. 1993;19(2):69-73.
The effect of Swertia chirata has been studied on experimentally induced gastric ulcers in rats. The ethanolic extract of chirata significantly reduced the intensity of gastric mucosal damage induced by indomethacin and necrotizing agents. It produced a significant decrease in gastric secretion in pylorus-ligated rats. The extract inhibited acetylcholine-induced contraction of guinea pig ileum, suggesting its anti-cholinergic activity. Pretreatment of rats with the extract significantly prevented ethanol-induced gastric wall mucus depletion and restored the non-protein sulfhydryl (NP-SH) content in the glandular stomachs. These findings support the use of chirata for the treatment of gastric ulcers in traditional medicine.
已对印度獐牙菜对实验性诱导的大鼠胃溃疡的作用进行了研究。獐牙菜的乙醇提取物显著降低了吲哚美辛和坏死剂诱导的胃黏膜损伤强度。它使幽门结扎大鼠的胃液分泌显著减少。该提取物抑制乙酰胆碱诱导的豚鼠回肠收缩，表明其具有抗胆碱能活性。用该提取物对大鼠进行预处理可显著预防乙醇诱导的胃壁黏液消耗，并恢复腺胃中的非蛋白巯基（NP-SH）含量。这些发现支持了传统医学中使用獐牙菜治疗胃溃疡。
