真核生物信使核糖核酸中的3'非编码区序列。
3' non-coding region sequences in eukaryotic messenger RNA.
作者信息
Proudfoot N J, Brownlee G G
出版信息
Nature. 1976 Sep 16;263(5574):211-4. doi: 10.1038/263211a0.
The sequence A-A-U-A-A-A is present in six different purified messenger RNA molecules (specifically the alpha-and beta-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRNA of mouse (MOPC 21) and the ovalbumin mRNA of chicken) about 20 residues away from the 3'-terminal poly (A) sequence. In addition, a large selection of the 3' non-coding regions of rabbit and human globulin mRNAs (both the alpha and beta globin mRNAs) are 85% homologous, demonstrating that this region is significantly conserved in evolution.
序列A-A-U-A-A-A存在于六个不同的纯化信使RNA分子中（具体为兔和人的α-和β-球蛋白信使RNA、小鼠（MOPC 21）的免疫球蛋白轻链信使RNA以及鸡的卵清蛋白信使RNA），距离3'-末端多聚（A）序列约20个残基。此外，兔和人球蛋白信使RNA（α和β球蛋白信使RNA）的3'非编码区的大量片段具有85%的同源性，表明该区域在进化过程中显著保守。
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