Ramani M, Ollivier V, Khechai F, Vu T, Ternisien C, Bridey F, de Prost D
INSERM U294, CHU Xavier Bichat, Paris, France.
FEBS Lett. 1993 Nov 8;334(1):114-6. doi: 10.1016/0014-5793(93)81693-t.
In Gram-negative septic shock, human monocytes synthesize and express on their cytoplasmic membrane tissue factor (TF), a potent activator of the coagulation cascades. The role of TF in triggering disseminated intravascular coagulation (DIC) in these patients appears to be clear. We report the suppressive effect of interleukin-10 (IL-10) on endotoxin-induced TF activity and antigen levels, and on the expression of TF mRNA levels in human monocytes. These results emphasize the potential therapeutic value of this cytokine in septic shock, a condition still associated with a high mortality rate.