HIR4 - 1突变定义了酿酒酵母中一类新的组蛋白调控基因。
The HIR4-1 mutation defines a new class of histone regulatory genes in Saccharomyces cerevisiae.
作者信息
Spector M S, Osley M A
机构信息
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
出版信息
Genetics. 1993 Sep;135(1):25-34. doi: 10.1093/genetics/135.1.25.
Abstract
Both activation and repression have been implicated in the cell cycle-regulated transcription of the histone HTA1-HTB1 locus in Saccharomyces cerevisiae. Transcriptional repressors have been identified through the isolation of recessive mutations in the HIR1, HIR2 and HIR3 genes. These three regulatory genes encode proteins that act at a negative site in the HTA1-HTB1 promoter, and their inactivation results in cell cycle-independent transcription. We report here on the characterization of a fourth HIR mutant. The HIR4-1 mutation is dominant, and the phenotypes that it confers suggest that the mutant gene encodes an altered transcriptional activator. The function of this activator is very specific: it uniquely regulates transcription of the HTA1-HTB1 locus, and it may antagonize repressors that act through the HTA1-HTB1 negative site.
摘要
在酿酒酵母中，激活和抑制都与组蛋白HTA1-HTB1基因座的细胞周期调控转录有关。通过分离HIR1、HIR2和HIR3基因中的隐性突变，已鉴定出转录抑制因子。这三个调控基因编码在HTA1-HTB1启动子的负性位点起作用的蛋白质，它们的失活导致细胞周期非依赖性转录。我们在此报告第四个HIR突变体的特征。HIR4-1突变是显性的，其赋予的表型表明突变基因编码一种改变的转录激活因子。这种激活因子的功能非常特异：它独特地调节HTA1-HTB1基因座的转录，并且可能拮抗通过HTA1-HTB1负性位点起作用的抑制因子。
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本文引用的文献
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