组蛋白调节（hir）突变可抑制酿酒酵母中的δ插入等位基因。
Histone regulatory (hir) mutations suppress delta insertion alleles in Saccharomyces cerevisiae.
作者信息
Sherwood P W, Osley M A
机构信息
Program in Molecular Biology, Sloan Kettering Cancer Center, New York, New York.
出版信息
Genetics. 1991 Aug;128(4):729-38. doi: 10.1093/genetics/128.4.729.
Abstract
Changes in histone gene dosage as well as mutations within some histone genes suppress delta insertion mutations in the HIS4 and LYS2 loci of Saccharomyces cerevisiae by altering the site of transcription initiation. We have found that three histone regulatory (hir) mutations, identified by their effects on the regulation of histone gene expression, suppress the same insertion mutations. In addition, we have examined whether any previously identified spt (suppressor of Ty) mutations might suppress the delta insertion alleles because of effects on histone gene regulation. Our results demonstrate that mutations in the histone genes SPT11/HTA1 and SPT12/HTB1 and in three other SPT genes, SPT1, SPT10 and SPT21, confer Hir- phenotypes. The spt1 mutation was found to be an allele of HIR2 while the spt10 and spt21 mutations are not in any of the known HIR genes.
摘要
组蛋白基因剂量的变化以及某些组蛋白基因内的突变，通过改变转录起始位点，抑制酿酒酵母HIS4和LYS2基因座中的δ插入突变。我们发现，通过对组蛋白基因表达调控的影响鉴定出的三个组蛋白调控（hir）突变，抑制相同的插入突变。此外，我们研究了之前鉴定出的任何spt（Ty抑制子）突变是否可能由于对组蛋白基因调控的影响而抑制δ插入等位基因。我们的结果表明，组蛋白基因SPT11/HTAⅠ和SPT12/HTB1以及其他三个SPT基因SPT1、SPT10和SPT21中的突变赋予Hir-表型。发现spt1突变是HIR2的一个等位基因，而spt10和spt21突变不在任何已知的HIR基因中。
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本文引用的文献
1
Cell-cycle regulation of yeast histone mRNA.酵母组蛋白mRNA的细胞周期调控
Cell. 1981 May;24(2):367-75. doi: 10.1016/0092-8674(81)90326-3.
2
Periodic transcription of yeast histone genes.酵母组蛋白基因的周期性转录。
Cell. 1982 Aug;30(1):305-10. doi: 10.1016/0092-8674(82)90036-8.
3
A new mapping method employing a meiotic rec-mutant of yeast.一种采用酵母减数分裂rec突变体的新映射方法。
Genetics. 1982 Mar;100(3):387-412. doi: 10.1093/genetics/100.3.387.
4
Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae.影响酿酒酵母HIS4基因Ty介导表达的突变。
Genetics. 1984 Jun;107(2):179-97. doi: 10.1093/genetics/107.2.179.
5
Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast.含有核糖体蛋白51内含子的β-半乳糖苷酶基因的表达对酵母的rna2突变敏感。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4403-7. doi: 10.1073/pnas.80.14.4403.
6
DNA rearrangements associated with a transposable element in yeast.酵母中与转座元件相关的DNA重排
Cell. 1980 Aug;21(1):239-49. doi: 10.1016/0092-8674(80)90131-2.
7
Insertion of the eukaryotic transposable element Ty1 creates a 5-base pair duplication.真核转座因子Ty1的插入会产生一个5碱基对的重复序列。
Nature. 1980 Jul 24;286(5771):352-6. doi: 10.1038/286352a0.
8
RNA from the yeast transposable element Ty1 has both ends in the direct repeats, a structure similar to retrovirus RNA.来自酵母转座因子Ty1的RNA在直接重复序列中都有两端，这种结构类似于逆转录病毒RNA。
Proc Natl Acad Sci U S A. 1983 May;80(9):2432-6. doi: 10.1073/pnas.80.9.2432.
9
The SPT3 gene is required for normal transcription of Ty elements in S. cerevisiae.SPT3基因是酿酒酵母中Ty元件正常转录所必需的。
Cell. 1984 Dec;39(3 Pt 2):675-82. doi: 10.1016/0092-8674(84)90474-4.
10
Effects of Ty insertions on HIS4 transcription in Saccharomyces cerevisiae.Ty 插入对酿酒酵母中 HIS4 转录的影响。
Mol Cell Biol. 1984 Jul;4(7):1246-51. doi: 10.1128/mcb.4.7.1246-1251.1984.
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