• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2.

作者信息

Kurabayashi M, Jeyaseelan R, Kedes L

机构信息

Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033.

出版信息

Gene. 1993 Nov 15;133(2):305-6. doi: 10.1016/0378-1119(93)90658-p.

DOI:10.1016/0378-1119(93)90658-p
PMID:8224921
Abstract

Two distinct Id2 cDNA clones, Id2A and Id2B (inhibitor of differentiation), have been isolated from a human heart cDNA library and sequenced. The deduced amino acid sequences show nearly complete identity, except for the nonsense mutation at codon 37 in Id2B. Characterization of the genomic clones revealed that Id2B is encoded by an intronless gene which probably arose after the evolutionary divergence of rats and humans.

摘要

相似文献

1
Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2.
Gene. 1993 Nov 15;133(2):305-6. doi: 10.1016/0378-1119(93)90658-p.
2
The mouse Id2 and Id4 genes: structural organization and chromosomal localization.小鼠Id2和Id4基因：结构组织与染色体定位。
Gene. 1998 Nov 19;222(2):229-35. doi: 10.1016/s0378-1119(98)00488-0.
3
The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3.新型显性负性螺旋-环-螺旋蛋白Id4的表达模式与Id1、Id2和Id3不同。
Nucleic Acids Res. 1994 Mar 11;22(5):749-55. doi: 10.1093/nar/22.5.749.
4
Neuronal expression of regulatory helix-loop-helix factor Id2 gene in mouse.小鼠中调控性螺旋-环-螺旋因子Id2基因的神经元表达
Dev Biol. 1993 Nov;160(1):186-95. doi: 10.1006/dbio.1993.1297.
5
Helix-loop-helix transcription factors regulate Id2 gene promoter activity.螺旋-环-螺旋转录因子调控Id2基因启动子活性。
FEBS Lett. 1995 Oct 30;374(2):279-83. doi: 10.1016/0014-5793(95)01128-2.
6
Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins.编码人螺旋-环-螺旋Id-1蛋白的cDNA的核苷酸序列：Id蛋白共有的功能保守残基的鉴定
Biochim Biophys Acta. 1994 Sep 13;1219(1):160-2. doi: 10.1016/0167-4781(94)90261-5.
7
Sequences of the 5'-flanking region of the human helix-loop-helix protein-encoding Id2A gene, and promoter activity regulated by serum and c-Jun/AP-1.人类编码螺旋-环-螺旋蛋白的Id2A基因5'-侧翼区序列，以及受血清和c-Jun/AP-1调节的启动子活性。
Gene. 1995 Apr 24;156(2):311-2. doi: 10.1016/0378-1119(95)00017-z.
8
Id2 is a primary partner for the E2-2 basic helix-loop-helix transcription factor in the human placenta.Id2是人类胎盘中E2-2碱性螺旋-环-螺旋转录因子的主要伙伴。
Mol Cell Endocrinol. 2004 Jul 30;222(1-2):83-91. doi: 10.1016/j.mce.2004.04.016.
9
Regulation of TCF ETS-domain transcription factors by helix-loop-helix motifs.通过螺旋-环-螺旋基序对TCF ETS结构域转录因子的调控
Nucleic Acids Res. 2003 Aug 15;31(16):4717-28. doi: 10.1093/nar/gkg689.
10
Identification in a fish species of two Id (inhibitor of DNA binding/differentiation)-related helix-loop-helix factors expressed in the slow oxidative muscle fibers.在一种鱼类的慢氧化肌纤维中鉴定出两种与Id（DNA结合/分化抑制因子）相关的螺旋-环-螺旋因子。
Eur J Biochem. 1997 Aug 1;247(3):870-6. doi: 10.1111/j.1432-1033.1997.00870.x.

引用本文的文献

1
Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas.功能基因表达分析揭示侵袭性葡萄膜黑色素瘤的表型转换。
Cancer Res. 2006 May 1;66(9):4602-9. doi: 10.1158/0008-5472.CAN-05-4196.
2
Helix-loop-helix proteins in mammary gland development and breast cancer.螺旋-环-螺旋蛋白在乳腺发育和乳腺癌中的作用
J Mammary Gland Biol Neoplasia. 2003 Apr;8(2):225-39. doi: 10.1023/a:1025957025773.
3
Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes.
DNA结合抑制因子（Id）与脂肪细胞决定和分化因子1/固醇调节元件结合蛋白-1c（ADD1/SREBP-1c）反式因子之间的功能拮抗作用对脂肪细胞中脂肪酸合酶启动子的调控。
Biochem J. 1999 Dec 15;344 Pt 3(Pt 3):873-80.
4
Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors.Id2通过一种独立于与碱性螺旋-环-螺旋因子二聚化的新机制促进细胞凋亡。
Mol Cell Biol. 1998 Sep;18(9):5435-44. doi: 10.1128/MCB.18.9.5435.
5
Inhibition of muscle-specific gene expression by Id3: requirement of the C-terminal region of the protein for stable expression and function.Id3对肌肉特异性基因表达的抑制作用：蛋白质C末端区域对稳定表达和功能的需求。
Nucleic Acids Res. 1997 Jan 15;25(2):423-30. doi: 10.1093/nar/25.2.423.
6
E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice.E盒位点和肌肉肌酸激酶基因的近端调控区域对转基因小鼠不同骨骼肌和心肌中的表达进行差异调节。
Mol Cell Biol. 1996 Sep;16(9):5058-68. doi: 10.1128/MCB.16.9.5058.
7
Doxorubicin-induced Id2A gene transcription is targeted at an activating transcription factor/cyclic AMP response element motif through novel mechanisms involving protein kinases distinct from protein kinase C and protein kinase A.阿霉素诱导的Id2A基因转录通过涉及不同于蛋白激酶C和蛋白激酶A的蛋白激酶的新机制，靶向激活转录因子/环磷酸腺苷反应元件基序。
Mol Cell Biol. 1995 Nov;15(11):6386-97. doi: 10.1128/MCB.15.11.6386.