Man K M, Drejet A, Keeffe E B, Garcia-Kennedy R, Imperial J C, Esquivel C O
Department of Transplantation, California Pacific Medical Center, San Francisco 94115.
Hepatology. 1993 Nov;18(5):1127-31.
Three patients with primary sclerosing cholangitis and Hodgkin's disease, a previously unrecognized association, are reported. All three patients were men, and one patient had Crohn's disease of the colon. Primary sclerosing cholangitis was diagnosed 2, 11 and 17 yr before diagnosis of Hodgkin's disease in the three patients, and all three had advanced biliary cirrhosis prompting referral for liver transplantation. The symptoms of Hodgkin's disease were often masked by similar manifestations of primary sclerosing cholangitis, particularly symptoms of recurrent biliary sepsis. Hodgkin's disease is another disorder that may occur in patients with primary sclerosing cholangitis, particularly in the setting of advanced disease, and may be masked by the underlying hepatobiliary disease.
本文报告了3例原发性硬化性胆管炎合并霍奇金病的患者，这是一种此前未被认识到的关联。所有3例患者均为男性，其中1例患有结肠克罗恩病。3例患者在霍奇金病诊断前2年、11年和17年被诊断为原发性硬化性胆管炎，且3例均有晚期胆汁性肝硬化，因此转诊进行肝移植。霍奇金病的症状常被原发性硬化性胆管炎的相似表现所掩盖，尤其是复发性胆系感染的症状。霍奇金病是另一种可能发生在原发性硬化性胆管炎患者中的疾病，尤其是在疾病晚期，且可能被潜在的肝胆疾病所掩盖。
