Kern W V, Engel A, Schieffer S, Prümmer O, Kern P
Section of Infectious Diseases and Clinical Immunology, Ulm University Hospital, Germany.
Infect Immun. 1993 Dec;61(12):5413-6. doi: 10.1128/iai.61.12.5413-5416.1993.
Cell surface components of viridans streptococci and enterococci have been shown to stimulate the release of tumor necrosis factor alpha (TNF) and interleukin-6 from monocytes/macrophages. In the sera from 10 patients with subacute enterococcal or streptococcal endocarditis, however, the levels of both cytokines were low or undetectable, with elevated TNF levels on admission in 3 patients with complicated disease. Soluble TNF receptor levels were significantly elevated compared with those of healthy controls. When patients with malaria were used as a control group of acute intravascular infection with high circulating TNF values, the ratio between soluble TNF receptors and TNF on admission was significantly greater in the patients with subacute bacterial endocarditis. Besides different amounts of circulating TNF, enhanced TNF receptor shedding may have an important role in the pathogenesis of subacute versus acute clinical disease following human intravascular infection.
草绿色链球菌和肠球菌的细胞表面成分已被证明可刺激单核细胞/巨噬细胞释放肿瘤坏死因子α（TNF）和白细胞介素-6。然而，在10例亚急性肠球菌或链球菌性心内膜炎患者的血清中，这两种细胞因子的水平均较低或无法检测到，3例合并复杂疾病的患者入院时TNF水平升高。与健康对照组相比，可溶性TNF受体水平显著升高。当将疟疾患者作为急性血管内感染且循环TNF值高的对照组时，亚急性细菌性心内膜炎患者入院时可溶性TNF受体与TNF的比值显著更高。除了循环TNF量不同外，TNF受体脱落增强可能在人类血管内感染后的亚急性与急性临床疾病发病机制中起重要作用。
