Kern W V, Oristrell J, Segura-Porta F, Kern P
Section of Infectious Diseases and Clinical Immunology, University Hospital, Ulm, Germany.
Clin Diagn Lab Immunol. 1996 Mar;3(2):233-5. doi: 10.1128/cdli.3.2.233-235.1996.
Tumor necrosis factor alpha (TNF) is a key cytokine in the defense against many intracellular pathogens, including Rickettsia conorii, the causative agent of Mediterranean spotted fever (MSF). The levels of two soluble TNF receptors (sTNFR-p55 and sTNFR-p75), the extracellular domains of the two cell surface receptors for TNF, were elevated in the acute-stage plasma samples from 20 patients with serologically confirmed MSF. The median values were 3.1 and 7.8 ng/ml for sTNFR-p55 and sTNFR-p75, respectively. sTNFR values correlated significantly with plasma TNF concentrations. Patients with severe MSF had higher values for both receptor fragments than patients with nonsevere disease. The differences were statistically significant for sTNFR-p55 (median, 5.8 versus 2.0 ng/ml; P = 0.008). Given the proportionately higher values for both TNF and sTNFR-p55 in patients with severe MSF, the sTNFR-p55/TNF ratios for the two patient subgroups did not differ (P = 0.5), while the sTNFR-p75/TNF ratios were significantly different (P = 0.01), with disproportionately lower values in patients with severe disease.
肿瘤坏死因子α（TNF）是抵御包括地中海斑疹热（MSF）病原体康氏立克次体在内的多种细胞内病原体的关键细胞因子。20例血清学确诊为MSF的患者急性期血浆样本中，两种可溶性TNF受体（sTNFR-p55和sTNFR-p75，即TNF两种细胞表面受体的胞外结构域）水平升高。sTNFR-p55和sTNFR-p75的中位数分别为3.1 ng/ml和7.8 ng/ml。sTNFR值与血浆TNF浓度显著相关。重症MSF患者的两种受体片段值均高于非重症患者。sTNFR-p55差异有统计学意义（中位数，5.8对2.0 ng/ml；P = 0.008）。鉴于重症MSF患者中TNF和sTNFR-p55的值相对较高，两个患者亚组的sTNFR-p55/TNF比值无差异（P = 0.5），而sTNFR-p75/TNF比值有显著差异（P = 0.01），重症患者的值相对较低。
