Janknegt R, Schepers J P, Haest J W, Fabius G T, Lohman J J, Smeets A P
Dept. of Clinical Pharmacy & Toxicology, Maasland Hospital Sittard/Geleen, The Netherlands.
Infection. 1993 Jul-Aug;21(4):214-9. doi: 10.1007/BF01728891.
A double-blind, randomized comparative study of piperacillin (2 g) versus amoxicillin-clavulanic acid (2.2 g) as a single dose 30 minutes before the initiation of hysterectomy was performed. A total of 595 patients (of which 307 were in the piperacillin group) were evaluable for efficacy. Infectious complications were infrequent in both arms. One case of (mild) sepsis was observed in the piperacillin group and two cases of wound infection were observed in the amoxicillin-clavulanic acid group. Urinary tract infection was observed in 5.5% of the patients in the piperacillin group and in 2.4% of the amoxicillin-clavulanic acid group. A relatively high incidence of asymptomatic bacteriuria was seen in both groups: 11.8% in the piperacillin group and 8.7% with amoxicillin-clavulanic acid. A marked difference was seen between the two different hospital locations: a 15% incidence in the hospital where midstream urine was used for culture (Sittard), versus 5% in the hospital where catheter urine was used (Geleen). It is concluded that both antibiotics are associated with a low rate of infectious complications and that catheter urine must be used for sample collection.
在子宫切除术开始前30分钟，进行了一项哌拉西林（2克）与阿莫西林 - 克拉维酸（2.2克）单剂量的双盲随机对照研究。共有595例患者（其中307例在哌拉西林组）可评估疗效。两组的感染并发症均不常见。在哌拉西林组观察到1例（轻度）败血症，在阿莫西林 - 克拉维酸组观察到2例伤口感染。哌拉西林组5.5%的患者和阿莫西林 - 克拉维酸组2.4%的患者出现尿路感染。两组无症状菌尿的发生率相对较高：哌拉西林组为11.8%，阿莫西林 - 克拉维酸组为8.7%。两个不同医院地点之间存在明显差异：使用中段尿进行培养的医院（锡塔德）发生率为15%，而使用导尿管尿液的医院（盖伦）发生率为5%。结论是两种抗生素的感染并发症发生率都很低，并且必须使用导尿管尿液进行样本采集。
