George A O, Akanji A O, Nduka E U, Olasode J B, Odusan O
Department of Medicine, University College Hospital, Ibadan, Nigeria.
Int J Dermatol. 1993 Oct;32(10):714-6. doi: 10.1111/j.1365-4362.1993.tb02739.x.
Acne keloidalis (AK) is an important cause of morbidity in Nigeria and accounts for 1.3% of patients with skin conditions in a Nigerian dermatology clinic. Treatment is usually unsatisfactory because the etiopathogenesis is unclear.
A prospective clinico-pathological study was carried out to identify predisposing factors, viable treatment modalities, and prognostic indicators.
The study suggested that AK is associated with the male gender seborrheic constitution, early reproductive years, and increased fasting blood testosterone concentration. Features that may predispose to the vastly predominant occipital location of the lesions include increased mast cell density and dilatation of dermal capillaries.
The main aims are diagnosis of early papules and avoidance of physical and chemical traumatizing agents. Retinoic acid analogs and antiandrogens may be helpful.
The widespread use of irritating physical and chemical traditional treatment remedies and delay in seeking medical attention--AK is typically asymptomatic--contribute to the relatively advanced nature of the disease at the time of presentation to the specialist.
瘢痕疙瘩性痤疮（AK）是尼日利亚发病的一个重要原因，在尼日利亚皮肤科诊所的皮肤病患者中占1.3%。由于发病机制尚不清楚，治疗通常不尽人意。
开展了一项前瞻性临床病理研究，以确定诱发因素、可行的治疗方式和预后指标。
该研究表明，AK与男性、脂溢性体质、生殖早期以及空腹血睾酮浓度升高有关。可能导致病变主要集中在枕部的特征包括肥大细胞密度增加和真皮毛细血管扩张。
主要目标是早期丘疹的诊断以及避免物理和化学创伤性因素。维甲酸类似物和抗雄激素药物可能会有帮助。
刺激性物理和化学传统治疗方法的广泛使用以及因AK通常无症状而导致就医延迟，使得该病在就诊于专科医生时病情相对较严重。
