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NADH-quinone oxidoreductase, the most complex complex.

作者信息

Ohnishi T

机构信息

Department of Biochemistry and Biophysics, University of Pennsylvania, Johnson Research Foundation, Philadelphia 19104-6089.

出版信息

J Bioenerg Biomembr. 1993 Aug;25(4):325-9. doi: 10.1007/BF00762457.

DOI:10.1007/BF00762457
PMID:8226713
Abstract
摘要

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NADH-quinone oxidoreductase, the most complex complex.NADH-醌氧化还原酶，最为复杂的复合体。
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2
Attempts to define distinct parts of NADH:ubiquinone oxidoreductase (complex I).对NADH：泛醌氧化还原酶（复合体I）不同部分进行定义的尝试。
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4
Identification of the coupling step in Na(+)-translocating NADH:quinone oxidoreductase from real-time kinetics of electron transfer.通过电子转移实时动力学鉴定钠转运型NADH：醌氧化还原酶中的偶联步骤。
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Structure of the respiratory NADH:ubiquinone oxidoreductase (complex I).呼吸链NADH：泛醌氧化还原酶（复合体I）的结构
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6
Steady-state kinetics of the reduction of coenzyme Q analogs by complex I (NADH:ubiquinone oxidoreductase) in bovine heart mitochondria and submitochondrial particles.牛心线粒体和亚线粒体颗粒中复合物I（NADH：泛醌氧化还原酶）还原辅酶Q类似物的稳态动力学。
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Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase.抑制剂在NADH：泛醌氧化还原酶（复合体I）中的两个结合位点。其中一个位点与细菌葡萄糖：泛醌氧化还原酶的泛醌结合位点的关系。
Eur J Biochem. 1994 Jan 15;219(1-2):691-8. doi: 10.1111/j.1432-1033.1994.tb19985.x.
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Interaction of ubiquinone and vitamin K3 with mitochondrial succinate-ubiquinone oxidoreductase.泛醌和维生素K3与线粒体琥珀酸-泛醌氧化还原酶的相互作用。
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Characterization of the reaction of decoupling ubiquinone with bovine mitochondrial respiratory complex I.泛醌与牛线粒体呼吸复合物I解偶联反应的表征
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本文引用的文献

1
Structural organization of complex I from bovine mitochondria.牛线粒体复合物I的结构组织
Biochem Soc Trans. 1993 Feb;21(1):26-31. doi: 10.1042/bst0210026.
2
The bacterial energy-transducing NADH-quinone oxidoreductases.细菌能量转换型NADH-醌氧化还原酶。
Biochim Biophys Acta. 1993 Feb 8;1141(1):1-17. doi: 10.1016/0005-2728(93)90182-f.
3
Binuclear centre structure of terminal protonmotive oxidases.末端质子动力氧化酶的双核中心结构
Cancers (Basel). 2023 Jan 24;15(3):705. doi: 10.3390/cancers15030705.
4
Iron-sulfur cluster N5 is coordinated by an HXXXCXXCXXXXXC motif in the NuoG subunit of Escherichia coli NADH:quinone oxidoreductase (complex I).铁硫簇N5由大肠杆菌NADH：醌氧化还原酶（复合体I）的NuoG亚基中的一个HXXXCXXCXXXXXC基序配位。
J Biol Chem. 2008 Sep 19;283(38):25979-87. doi: 10.1074/jbc.M804015200. Epub 2008 Jul 4.
5
Introduction: complex I--an L-shaped black box.
J Bioenerg Biomembr. 2001 Jun;33(3):155-7. doi: 10.1023/a:1010702116348.
6
The respiratory complex I in yeast: isolation of a gene NUO51 coding for the nucleotide-binding subunit of NADH:ubiquinone oxidoreductase from the obligately aerobic yeast Yarrowia lipolytica.酵母中的呼吸链复合体I：从专性需氧酵母解脂耶氏酵母中分离出编码NADH：泛醌氧化还原酶核苷酸结合亚基的基因NUO51。
Folia Microbiol (Praha). 2000;45(5):429-33. doi: 10.1007/BF02817616.
7
Proton pumping of mitochondrial complex I: differential activation by analogs of ubiquinone.线粒体复合物I的质子泵浦：泛醌类似物的差异激活作用
J Bioenerg Biomembr. 1997 Feb;29(1):71-80. doi: 10.1023/a:1022415906999.
8
The plant mitochondrial 22 kDa (PSST) subunit of respiratory chain complex I is encoded by a nuclear gene with enhanced transcript levels in flowers.植物呼吸链复合体I的22 kDa（PSST）线粒体亚基由一个核基因编码，该基因在花中的转录水平增强。
Plant Mol Biol. 1996 Sep;31(6):1195-204. doi: 10.1007/BF00040836.
9
The specificity of mitochondrial complex I for ubiquinones.线粒体复合体I对泛醌的特异性。
Biochem J. 1996 Jan 1;313 ( Pt 1)(Pt 1):327-34. doi: 10.1042/bj3130327.
10
Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I).番荔枝科的天然物质（乙酰精）是线粒体NADH脱氢酶（复合体I）的强效抑制剂。
Biochem J. 1994 Jul 1;301 ( Pt 1)(Pt 1):161-7. doi: 10.1042/bj3010161.
FEBS Lett. 1993 Feb 1;316(3):216-23. doi: 10.1016/0014-5793(93)81296-c.
4
New insights, ideas and unanswered questions concerning iron-sulfur clusters in mitochondria.关于线粒体中铁硫簇的新见解、观点及未解决的问题。
Biochim Biophys Acta. 1982 Dec 31;683(3-4):245-77. doi: 10.1016/0304-4173(82)90003-9.
5
On the nature of the spin coupling between the iron-sulfur clusters in the eight-iron ferredoxins.关于八铁铁氧化还原蛋白中铁硫簇之间自旋耦合的本质。
J Biol Chem. 1974 Jul 10;249(13):4326-8.
6
Relation of the respiratory chain-linked reduced nicotinamide--adenine dinucleotide dehydrogenase to energy-coupling site 1.呼吸链连接的还原型烟酰胺腺嘌呤二核苷酸脱氢酶与能量偶联部位1的关系。
Biochemistry. 1972 Feb 15;11(4):556-62. doi: 10.1021/bi00754a012.
7
Mitochondrial origins.线粒体起源
Proc Natl Acad Sci U S A. 1985 Jul;82(13):4443-7. doi: 10.1073/pnas.82.13.4443.
8
NADH-ubiquinone oxidoreductases of the Escherichia coli aerobic respiratory chain.大肠杆菌有氧呼吸链的NADH-泛醌氧化还原酶
Biochemistry. 1987 Dec 1;26(24):7732-7. doi: 10.1021/bi00398a029.
9
The mitochondrial electron transport and oxidative phosphorylation system.线粒体电子传递与氧化磷酸化系统。
Annu Rev Biochem. 1985;54:1015-69. doi: 10.1146/annurev.bi.54.070185.005055.
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The molecular pathology of respiratory-chain dysfunction in human mitochondrial myopathies.
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