Tyler H, Ramsey H
Department of Animal Science, College of Agriculture and Life Sciences, North Carolina State University, Raleigh 27695-7621.
J Dairy Sci. 1993 Oct;76(10):3021-5. doi: 10.3168/jds.S0022-0302(93)77641-9.
Fructose was used as a hypoglycemic agent to determine whether availability of glucose during early life mediates the cessation of intestinal transport of Ig (closure). Either glucose or fructose (100 g in 2 L of electrolyte solution) was fed to calves deprived of colostrum at 3, 6, 9, 12, 15, 18, and 21 h postpartum. Colostrum (1 kg) was fed to all calves at 24, 36, and 48 h postpartum. Venous blood was sampled, and plasma was harvested, for the measurement of glucose, fructose, insulin, and IgG. During the first 24 h, means for plasma glucose from calves treated with glucose and fructose, respectively, were 282 and 24 mg/dl. The latter value reflects the degree of hypoglycemia induced by feeding fructose. During the same period, corresponding concentrations of plasma fructose were 4 and 230 mg/dl. Plasma insulin concentrations for precolostral calves were 101 and 11 microU/ml for calves treated with glucose and fructose, respectively. Peak IgG concentrations were extremely low for both groups of calves, indicating that intestinal transport of Ig had virtually ceased by the end of the 24-h treatment period. Thus, fructose-induced hypoglycemia had no effect on the time of intestinal closure in the newborn calf.
果糖被用作一种降血糖剂，以确定生命早期葡萄糖的可利用性是否介导了免疫球蛋白肠道转运的停止（封闭）。在产后3、6、9、12、15、18和21小时，将葡萄糖或果糖（100克溶于2升电解质溶液中）喂给未摄入初乳的犊牛。在产后24、36和48小时，给所有犊牛喂初乳（1千克）。采集静脉血并分离血浆，用于检测葡萄糖、果糖、胰岛素和免疫球蛋白G。在最初的24小时内，分别用葡萄糖和果糖处理的犊牛血浆葡萄糖均值分别为282和24毫克/分升。后一个值反映了喂食果糖诱导的低血糖程度。在同一时期，相应的血浆果糖浓度分别为4和230毫克/分升。初乳前犊牛血浆胰岛素浓度，用葡萄糖和果糖处理的犊牛分别为101和11微单位/毫升。两组犊牛的免疫球蛋白G峰值浓度都极低，这表明在24小时治疗期结束时，免疫球蛋白的肠道转运实际上已经停止。因此，果糖诱导的低血糖对新生犊牛肠道封闭的时间没有影响。
