Bogerts B, Falkai P, Greve B, Schneider T, Pfeiffer U
Department of Psychiatry, University of Düsseldorf, FRG.
J Hirnforsch. 1993;34(2):193-205.
Historical aspects of neuroanatomical schizophrenia research and recent findings in limbic and basal ganglia structures of schizophrenia are briefly reviewed. Then, results of volume measurements of these brain regions from 26 schizophrenics and 28 controls belonging to our new brain collection are presented. Volumes of the hippocampus, amygdala, stria terminalis and caudate were bilaterally significantly reduced, the internal pallidum showed a trend towards smaller volumes, while brain weight, putamen, nucleus accumbens and external pallidum were unchanged. The results give further evidence of subtle focal brain tissue reductions in schizophrenics. Finally, gaps in our present knowledge in the neuropathology of schizophrenia and some basic problems in this research field are discussed.
本文简要回顾了神经解剖学对精神分裂症研究的历史方面以及近期在精神分裂症边缘系统和基底神经节结构中的研究发现。然后，展示了从我们新的脑库中选取的26名精神分裂症患者和28名对照者这些脑区体积测量的结果。海马体、杏仁核、终纹床核和尾状核的体积双侧均显著减小，苍白球内部体积有减小的趋势，而脑重量、壳核、伏隔核和苍白球外部则无变化。这些结果进一步证明了精神分裂症患者存在细微的局灶性脑组织减少。最后，讨论了我们目前在精神分裂症神经病理学方面知识的空白以及该研究领域的一些基本问题。
