Increasing incidence of cryptococcosis in the United Kingdom.

The incidence of infection with Cryptococcus neoformans in the United Kingdom during the years between 1953 and 1981 is compared with that between 1982 and 1991. The patients were those from whom samples were submitted to the PHLS Mycological Reference Laboratory (MRL), or those in whom the disease was confirmed elsewhere in the United Kingdom and reported to PHLS Communicable Disease Surveillance Centre (CDSC). In all, 83 cases were identified between 1953 and 1981 and 322 between 1982 and 1991, 201 of which were known to be HIV-associated. The incidence of infection with Cryptococcus neoformans has increased four-fold in the last decade. It is an increasing cause of infection in immunosuppressed patients, most notably those with HIV infection. Currently, 4.0% patients with AIDS in the United Kingdom are known to have developed cryptococcosis.