Krajinovic M, Lazic J, Stanimirovic B, Diklic V, Savic A
Institute of Biology and Human Genetics, Medical School, University of Belgrade, Yugoslavia.
J Med Virol. 1993 Sep;41(1):1-5. doi: 10.1002/jmv.1890410102.
The presence of the E2 region of HPV 16 was determined by the polymerase chain reaction in biopsy samples with different histopathological diagnoses. The absence of the E2 gene was observed in 17 of 30 cases examined. The E2 deletions were not confined exclusively to invasive carcinomas or to integrated viral forms. In the majority of cases, the course of cervical lesions was consistent with the state of the E2 gene.
通过聚合酶链反应在具有不同组织病理学诊断的活检样本中确定人乳头瘤病毒16型E2区域的存在情况。在所检查的30例病例中，有17例观察到E2基因缺失。E2缺失并非仅局限于浸润性癌或整合病毒形式。在大多数病例中，宫颈病变进程与E2基因状态一致。
