Eversole L R, Miyasaki K T, Christensen R E
Section of Diagnostic Sciences, CHS 53-058 School of Dentistry, UCLA Center for the Health Sciences.
J Oral Pathol Med. 1993 Aug;22(7):303-7. doi: 10.1111/j.1600-0714.1993.tb01077.x.
Oral mucosal inflammation evolves in response to microbial pathogens and non-infectious antigens which activate humoral and cell-mediated immunologic processes. Most of these disease processes invoke a leukocyte response culminating in cellular infiltration of the submucosa and, to some degree, transmigration into the epithelium itself. Calprotectin, a leukocyte-derived dimeric protein complex that has potent antibacterial and antifungal effects, has recently been identified in skin and mucosal keratinocytes implying that epithelium may biochemically contribute to the overall mechanism of host defense. In this study, the upregulation of calprotectin as assessed immunohistochemically is pursued for oral diseases of immunopathologic, fungal and viral origin. In lichen planus, candidiasis, herpes virus stomatitis, and oral hairy leukoplakia, calprotectin was found to be expressed to a significantly higher level than in normal control mucosal samples.
口腔黏膜炎症是对微生物病原体和非感染性抗原作出反应而演变的，这些病原体和抗原会激活体液免疫和细胞介导的免疫过程。这些疾病过程大多会引发白细胞反应，最终导致黏膜下层细胞浸润，并在一定程度上迁移到上皮本身。钙卫蛋白是一种源自白细胞的二聚体蛋白复合物，具有强大的抗菌和抗真菌作用，最近在皮肤和黏膜角质形成细胞中被发现，这意味着上皮可能在生化方面有助于宿主防御的整体机制。在本研究中，通过免疫组织化学评估了钙卫蛋白在免疫病理、真菌和病毒源性口腔疾病中的上调情况。在扁平苔藓、念珠菌病、疱疹性口炎和口腔毛状白斑中，发现钙卫蛋白的表达水平明显高于正常对照黏膜样本。
