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在髓系白血病患者中,单核细胞抗原呈递能力受损与其 HLA-II 抗原表达降低相关。

Impaired antigen-presenting capability of monocytes correlated with their decreased expression of HLA-II antigens in patients with myeloid leukemia.

作者信息

Gong F L, Feng X W, Grosse-Wilde H

机构信息

Department of Immunology, Tongji Medical University, Wuhan.

出版信息

J Tongji Med Univ. 1993;13(2):65-70. doi: 10.1007/BF02887918.

DOI:10.1007/BF02887918
PMID:8230358
Abstract

Antigen-presenting capability and expression of HLA-II antigens on peripheral blood monocytes were analyzed by isotope incorporation technique and indirect immunofluorescence assay with monoclonal antibodies Tü 22, Tü 36 and anti-Leu-M2 in patients with acute and chronic myeloid leukemias (AML, CML). All patients (17 AML and 13 CML) demonstrated impaired antigen-presenting capability of monocytes (P < 0.001), when compared with simultaneously studied controls, which were HLA-identical normal siblings of the patients. These patients also showed a markedly decreased proportion of MAC-120- and HLA-DQ-positive monocytes as compared with the controls (P < 0.001), while the percentage of HLA-DR-positive monocytes in the patients was similar to that observed in the controls (P > 0.05). These findings suggested, therefore, that impaired antigen-presenting capability of monocytes correlated with their decreased expression of HLA-DQ in patients with acute and chronic myeloid leukemias.

摘要

采用同位素掺入技术以及用单克隆抗体Tü 22、Tü 36和抗Leu-M2进行间接免疫荧光测定,分析了急性和慢性髓系白血病(AML、CML)患者外周血单核细胞的抗原呈递能力以及HLA-II类抗原的表达。与同时研究的对照(即患者的HLA相同的正常同胞)相比,所有患者(17例AML和13例CML)的单核细胞抗原呈递能力均受损(P < 0.001)。与对照相比,这些患者的MAC-120和HLA-DQ阳性单核细胞比例也显著降低(P < 0.001),而患者中HLA-DR阳性单核细胞的百分比与对照中观察到的相似(P > 0.05)。因此,这些发现表明,急性和慢性髓系白血病患者单核细胞抗原呈递能力受损与其HLA-DQ表达降低相关。

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J Tongji Med Univ. 1993;13(2):65-70. doi: 10.1007/BF02887918.
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本文引用的文献

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Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester.人外周血中丝裂原刺激的T细胞和B细胞反应所需辅助细胞的表型:通过其对溶酶体亲和剂L-亮氨酸甲酯的敏感性来描述。
J Immunol. 1983 Nov;131(5):2282-90.
2
Cytofluorometric analysis of major histocompatibility antigens on human monocytes using monoclonal antibodies.
Hum Immunol. 1983 Jan;6(1):1-11. doi: 10.1016/0198-8859(83)90069-1.
3
The human autologous mixed lymphocyte reaction. I. Suppression by macrophages and T cells.人类自体混合淋巴细胞反应。I. 巨噬细胞和T细胞的抑制作用。
J Immunol. 1981 Nov;127(5):1987-93.
4
Antigen-presenting capabilities of human monocytes correlates with their expression of HLA-DS, an Ia determinant distinct from HLA-DR.人类单核细胞的抗原呈递能力与其HLA-DS的表达相关,HLA-DS是一种与HLA-DR不同的Ia决定簇。
J Immunol. 1983 Feb;130(2):706-11.
5
Histocompatibility matching. VI. Miniaturization of the mixed leukocyte culture test: a preliminary report.组织相容性匹配。VI. 混合淋巴细胞培养试验的小型化:初步报告。
Transplantation. 1971 Mar;11(3):268-73. doi: 10.1097/00007890-197103000-00005.
6
Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.豚鼠T淋巴细胞抗原识别中巨噬细胞的作用。I. 对组织相容性巨噬细胞和淋巴细胞的需求。
J Exp Med. 1973 Nov 1;138(5):1194-212. doi: 10.1084/jem.138.5.1194.
7
Divergent expression of HLA-DC/MB, -DR, and -SB region products on normal and pathological tissues as detected by monoclonal antibodies.
Immunobiology. 1985 Apr;169(3):228-49. doi: 10.1016/s0171-2985(85)80036-x.
8
Differential expression of HLA-DR and HLA-DQ antigens on normal cells of the myelomonocytic lineage.髓单核细胞系正常细胞上HLA-DR和HLA-DQ抗原的差异表达。
Tissue Antigens. 1985 Nov;26(5):310-7. doi: 10.1111/j.1399-0039.1985.tb02229.x.
9
HLA today.今日的人类白细胞抗原
Hum Immunol. 1986 Dec;17(4):490-503. doi: 10.1016/0198-8859(86)90307-1.
10
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J Immunol. 1986 Jul 15;137(2):519-24.