• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人疱疹病毒6B株Z29中DNA复制裂解期起源的鉴定。

Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29.

作者信息

Dewhurst S, Dollard S C, Pellett P E, Dambaugh T R

机构信息

Department of Microbiology and Immunology, University of Rochester, New York 14642.

出版信息

J Virol. 1993 Dec;67(12):7680-3. doi: 10.1128/JVI.67.12.7680-7683.1993.

DOI:10.1128/JVI.67.12.7680-7683.1993
PMID:8230490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC238241/
Abstract

DNA sequences which have structural features suggestive of their functioning as an origin of lytic-phase DNA replication were previously identified in both human herpesvirus 6B strain Z29 [HHV-6B (Z29)] and in HHV-6A (U1102). Plasmid constructs containing the putative HHV-6B (Z29) oriLyt element were replicated after transfection into permissive T cells, when trans-acting factors were provided by HHV-6B (R-1) infection. By using this assay, the HHV-6B (Z29) oriLyt was mapped to a minimal region of approximately 400 bp which lies upstream of the gene that is homologous to herpes simplex virus UL29, a region that carries an origin in other betaherpesviruses and in some alphaherpesviruses.

摘要

先前在人类疱疹病毒6B株Z29 [HHV-6B (Z29)] 和HHV-6A (U1102) 中均鉴定出具有结构特征、提示其作为裂解期DNA复制起点发挥作用的DNA序列。当通过HHV-6B (R-1) 感染提供反式作用因子时，含有推定的HHV-6B (Z29) oriLyt元件的质粒构建体在转染至允许性T细胞后得以复制。通过使用该检测方法，HHV-6B (Z29) oriLyt被定位到一个约400 bp的最小区域，该区域位于与单纯疱疹病毒UL29同源的基因上游，在其他β疱疹病毒和一些α疱疹病毒中该区域携带一个起点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/238241/7aa0779c16ce/jvirol00033-0779-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/238241/619577a39731/jvirol00033-0779-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/238241/7aa0779c16ce/jvirol00033-0779-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/238241/619577a39731/jvirol00033-0779-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b2/238241/7aa0779c16ce/jvirol00033-0779-b.jpg

相似文献

1
Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29.人疱疹病毒6B株Z29中DNA复制裂解期起源的鉴定。
J Virol. 1993 Dec;67(12):7680-3. doi: 10.1128/JVI.67.12.7680-7683.1993.
2
Copy Number Heterogeneity, Large Origin Tandem Repeats, and Interspecies Recombination in Human Herpesvirus 6A (HHV-6A) and HHV-6B Reference Strains.人疱疹病毒 6A（HHV-6A）和 HHV-6B 参考株中的拷贝数异质性、大片段串联重复和种间重组。
J Virol. 2018 Apr 27;92(10). doi: 10.1128/JVI.00135-18. Print 2018 May 15.
3
Genetic content of a 20.9 kb segment of human herpesvirus 6B strain Z29 spanning the homologs of human herpesvirus 6A genes U40-57 and containing the origin of DNA replication.人类疱疹病毒6B株Z29的一段20.9 kb片段的遗传内容，该片段跨越人类疱疹病毒6A基因U40 - 57的同源物并包含DNA复制起点。
Arch Virol. 1997;142(1):103-23. doi: 10.1007/s007050050062.
4
Identification and analysis of a lytic-phase origin of DNA replication in human herpesvirus 7.人类疱疹病毒7型裂解期DNA复制起点的鉴定与分析
J Virol. 1997 Apr;71(4):3279-84. doi: 10.1128/JVI.71.4.3279-3284.1997.
5
A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope.人类疱疹病毒6型B亚型Z29株的一种强免疫反应性病毒体蛋白：基因的鉴定与特征分析以及一种亚型特异性单克隆抗体反应表位的定位
Virology. 1993 Aug;195(2):521-31. doi: 10.1006/viro.1993.1403.
6
Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6.介导人疱疹病毒6型基因组切割与包装的顺式作用序列的功能鉴定与分析
J Virol. 1998 Jan;72(1):320-9. doi: 10.1128/JVI.72.1.320-329.1998.
7
Stringent structural and sequence requirements of the human herpesvirus 6B lytic-phase origin of DNA replication.人类疱疹病毒6B DNA复制裂解期起始点严格的结构和序列要求。
J Gen Virol. 1997 May;78 ( Pt 5):1125-9. doi: 10.1099/0022-1317-78-5-1125.
8
Sequence requirements for interaction of human herpesvirus 7 origin binding protein with the origin of lytic replication.人类疱疹病毒7型起始结合蛋白与裂解复制起始位点相互作用的序列要求
J Virol. 2001 Apr;75(8):3925-36. doi: 10.1128/JVI.75.8.3925-3936.2001.
9
Alphaherpesvirus origin-binding protein homolog encoded by human herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that are similar to ori regions of alphaherpesviruses.人疱疹病毒6B（一种β疱疹病毒）编码的α疱疹病毒起始结合蛋白同源物，可与类似于α疱疹病毒ori区域的核苷酸序列结合。
J Virol. 1994 Jul;68(7):4126-36. doi: 10.1128/JVI.68.7.4126-4136.1994.
10
Efficient propagation of human herpesvirus 6B in a T-cell line derived from a patient with adult T-cell leukemia/lymphoma.人类疱疹病毒6B在源自一名成人T细胞白血病/淋巴瘤患者的T细胞系中的高效增殖。
Microbiol Immunol. 1999;43(5):425-36. doi: 10.1111/j.1348-0421.1999.tb02426.x.

引用本文的文献

1
Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species.玫瑰疹病毒在人类、猪、鼠及其他物种中的比较分析。
Viruses. 2019 Nov 30;11(12):1108. doi: 10.3390/v11121108.
2
Small RNA deep sequencing identifies microRNAs and other small noncoding RNAs from human herpesvirus 6B.小 RNA 深度测序鉴定人疱疹病毒 6B 的 microRNAs 和其他小非编码 RNA。
J Virol. 2012 Feb;86(3):1638-49. doi: 10.1128/JVI.05911-11. Epub 2011 Nov 23.
3
Update on human herpesvirus 6 biology, clinical features, and therapy.人疱疹病毒6型生物学、临床特征及治疗进展

本文引用的文献

1
Antigenic and genetic differentiation of the two putative types of human herpes virus 6.两种假定的人类疱疹病毒6型的抗原性和基因分化
J Virol Methods. 1993 Feb;41(2):223-34. doi: 10.1016/0166-0934(93)90129-f.
2
Human herpesvirus-6 strain groups: a nomenclature.人类疱疹病毒6型毒株组：一种命名法。
Arch Virol. 1993;129(1-4):363-6. doi: 10.1007/BF01316913.
3
Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients.通过对实验室菌株以及来自霍奇金淋巴瘤和骨髓移植患者的病毒变体进行序列分析，鉴定出两组人类疱疹病毒6型。
Clin Microbiol Rev. 2005 Jan;18(1):217-45. doi: 10.1128/CMR.18.1.217-245.2005.
4
Identification of the rhesus macaque rhadinovirus lytic origin of DNA replication.恒河猴疱疹病毒DNA复制裂解起源的鉴定。
J Virol. 2001 Dec;75(23):11401-7. doi: 10.1128/JVI.75.23.11401-11407.2001.
5
Sequence requirements for interaction of human herpesvirus 7 origin binding protein with the origin of lytic replication.人类疱疹病毒7型起始结合蛋白与裂解复制起始位点相互作用的序列要求
J Virol. 2001 Apr;75(8):3925-36. doi: 10.1128/JVI.75.8.3925-3936.2001.
6
Evolutionary aspects of oncogenic herpesviruses.致癌性疱疹病毒的进化方面
Mol Pathol. 2000 Oct;53(5):222-37. doi: 10.1136/mp.53.5.222.
7
Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A.人类疱疹病毒6B基因组序列：编码内容及其与人类疱疹病毒6A的比较。
J Virol. 1999 Oct;73(10):8040-52. doi: 10.1128/JVI.73.10.8040-8052.1999.
8
Tamplicon-7, a novel T-lymphotropic vector derived from human herpesvirus 7.Tamplicon-7，一种源自人类疱疹病毒7的新型嗜T淋巴细胞载体。
J Virol. 1999 Aug;73(8):7001-7. doi: 10.1128/JVI.73.8.7001-7007.1999.
9
Identification of persistent RNA-DNA hybrid structures within the origin of replication of human cytomegalovirus.人巨细胞病毒复制起点内持续性RNA-DNA杂交结构的鉴定
J Virol. 1998 Sep;72(9):6997-7004. doi: 10.1128/JVI.72.9.6997-7004.1998.
10
Functional identification and analysis of cis-acting sequences which mediate genome cleavage and packaging in human herpesvirus 6.介导人疱疹病毒6型基因组切割与包装的顺式作用序列的功能鉴定与分析
J Virol. 1998 Jan;72(1):320-9. doi: 10.1128/JVI.72.1.320-329.1998.
J Gen Virol. 1993 Apr;74 ( Pt 4):613-22. doi: 10.1099/0022-1317-74-4-613.
4
Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants.人类疱疹病毒6型（HHV-6）B亚型在美国婴儿群体中，是大多数有症状的原发性HHV-6感染的病原体。
J Clin Microbiol. 1993 Feb;31(2):416-8. doi: 10.1128/jcm.31.2.416-418.1993.
5
cis-acting components in the replication origin from ribosomal DNA of Saccharomyces cerevisiae.酿酒酵母核糖体DNA复制起点中的顺式作用元件。
Mol Cell Biol. 1993 Sep;13(9):5360-9. doi: 10.1128/mcb.13.9.5360-5369.1993.
6
A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope.人类疱疹病毒6型B亚型Z29株的一种强免疫反应性病毒体蛋白：基因的鉴定与特征分析以及一种亚型特异性单克隆抗体反应表位的定位
Virology. 1993 Aug;195(2):521-31. doi: 10.1006/viro.1993.1403.
7
The herpes simplex virus amplicon: a new eucaryotic defective-virus cloning-amplifying vector.单纯疱疹病毒扩增子：一种新型真核缺陷病毒克隆扩增载体。
Cell. 1982 Aug;30(1):295-304. doi: 10.1016/0092-8674(82)90035-6.
8
Replication of herpes simplex virus DNA: localization of replication recognition signals within defective virus genomes.单纯疱疹病毒DNA的复制：复制识别信号在缺陷病毒基因组中的定位
Proc Natl Acad Sci U S A. 1981 Feb;78(2):742-6. doi: 10.1073/pnas.78.2.742.
9
Selective extraction of polyoma DNA from infected mouse cell cultures.从受感染的小鼠细胞培养物中选择性提取多瘤病毒DNA。
J Mol Biol. 1967 Jun 14;26(2):365-9. doi: 10.1016/0022-2836(67)90307-5.
10
A method for identifying the viral genes required for herpesvirus DNA replication.一种鉴定疱疹病毒DNA复制所需病毒基因的方法。
Proc Natl Acad Sci U S A. 1986 Dec;83(23):9094-8. doi: 10.1073/pnas.83.23.9094.