人类疱疹病毒7型裂解期DNA复制起点的鉴定与分析
Identification and analysis of a lytic-phase origin of DNA replication in human herpesvirus 7.
作者信息
van Loon N, Dykes C, Deng H, Dominguez G, Nicholas J, Dewhurst S
机构信息
Department of Microbiology and Immunology, Medical Center, University of Rochester, New York 14642, USA.
出版信息
J Virol. 1997 Apr;71(4):3279-84. doi: 10.1128/JVI.71.4.3279-3284.1997.
Abstract
Human herpesvirus 7 (HHV-7) DNA sequences colinear with the HHV-6 lytic-phase origin of DNA replication (oriLyt) were amplified by PCR. Plasmid constructs containing these sequences were replicated in HHV-7-infected cord blood mononuclear cells but not in HHV-6-infected cells. In contrast, plasmids bearing HHV-6 oriLyt were replicated in both HHV-6- and HHV-7-infected cells. Finally, the minimal HHV-7 DNA element necessary for replicator activity was mapped to a 600-bp region which contains two sites with high homology to the consensus binding site for the HHV-6 origin binding protein. At least one of these binding sites was shown to be essential for replicator function of HHV-7 oriLyt.
摘要
通过聚合酶链反应（PCR）扩增出与人类疱疹病毒6型（HHV-6）DNA复制裂解期起始点（oriLyt）共线的人类疱疹病毒7型（HHV-7）DNA序列。含有这些序列的质粒构建体在感染HHV-7的脐血单个核细胞中可复制，但在感染HHV-6的细胞中不能复制。相反，携带HHV-6 oriLyt的质粒在感染HHV-6和HHV-7的细胞中均可复制。最后，复制子活性所需的最小HHV-7 DNA元件被定位到一个600碱基对的区域，该区域包含两个与HHV-6起始点结合蛋白的共有结合位点具有高度同源性的位点。这些结合位点中至少有一个对于HHV-7 oriLyt的复制子功能至关重要。
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