Seeliger M W, Kretschmann U H, Apfelstedt-Sylla E, Zrenner E
University Eye Hospital, Department II, Tübingen, Germany.
Invest Ophthalmol Vis Sci. 1998 Apr;39(5):718-23.
To describe the implicit time topography of multifocal electroretinograms in normal subjects and to examine the change in this topography in patients affected by retinitis pigmentosa.
Thirty normal subjects and 38 patients with retinitis pigmentosa were examined with the Visual Evoked Response Imaging System using 61 hexagonal elements within a visual field of 30 degrees radius. The peak implicit times of the 61 first-order kernels (which are analogues of the photopic electroretinogram [ERG]) were measured to determine their distribution across the retina.
Implicit times had a low interindividual variability in the normal group. High implicit times were found at the blind spot, the upper and lower borders of the stimulated field, and the macula. Low values were present in the area encircling the macula and were most prominent in the temporal retina. In the group with retinitis pigmentosa, implicit times were unchanged in the central region but were prolonged in the peripheral regions.
The spatial distribution of multifocal ERG implicit times in a normal population follows a specific topographical pattern across the retina. This pattern has to be taken into account when interpreting results in patients. Deviations in retinitis pigmentosa were found, and they show the potential for diagnostic use.
描述正常受试者多焦视网膜电图的隐含时间地形图，并研究色素性视网膜炎患者该地形图的变化。
使用视觉诱发电位成像系统，对30名正常受试者和38名色素性视网膜炎患者进行检查，该系统在半径30度的视野范围内使用61个六边形单元。测量61个一阶核（类似于明视视网膜电图[ERG]）的峰值隐含时间，以确定它们在视网膜上的分布。
正常组中隐含时间的个体间变异性较低。在盲点、刺激野的上边界和下边界以及黄斑处发现隐含时间较长。在环绕黄斑的区域中隐含时间值较低，在颞侧视网膜中最为明显。在色素性视网膜炎组中，中央区域的隐含时间未改变，但周边区域的隐含时间延长。
正常人群中多焦ERG隐含时间的空间分布在整个视网膜上遵循特定的地形模式。在解释患者的结果时必须考虑到这种模式。在色素性视网膜炎中发现了偏差，它们显示出诊断用途的潜力。
