Ginsberg S D, Hof P R, McKinney W T, Morrison J H
Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029.
Neurosci Lett. 1993 Aug 20;158(2):130-4. doi: 10.1016/0304-3940(93)90246-h.
A series of neuroanatomic analyses have been undertaken to identify potential neuropathological changes seen in monkeys exposed to early social deprivation, which leads to psychopathology, inappropriate responses to stress and appetitive disorders. The animals used in this study were either socially reared or maternal- and peer-deprived. Within this framework, the distribution and density of noradrenergic (and adrenergic) varicosities was assessed in the hypothalamic paraventricular nucleus of rhesus monkeys using dopamine-beta-hydroxylase immunohistochemistry combined with laser scanning microscopy. Quantitative analysis of dopamine-beta-hydroxylase-immunoreactive varicosity density within magnocellular and parvicellular regions revealed no significant differences between rearing conditions, suggesting that this chemically identified afferent input to the paraventricular nucleus was not affected by the early environmental insult of social deprivation. The apparent lack of vulnerability of the paraventricular nucleus to differential rearing conditions contrasts with the neuropathological changes observed in several discrete brain regions.
已经进行了一系列神经解剖学分析，以确定在早期遭受社会剥夺的猴子中出现的潜在神经病理学变化，这种剥夺会导致精神病理学、对应激的不适当反应和食欲紊乱。本研究中使用的动物要么是在社会环境中饲养的，要么是被剥夺了母婴和同伴接触机会的。在此框架内，使用多巴胺-β-羟化酶免疫组织化学结合激光扫描显微镜，评估了恒河猴下丘脑室旁核中去甲肾上腺素能（和肾上腺素能）曲张体的分布和密度。对大细胞和小细胞区域内多巴胺-β-羟化酶免疫反应性曲张体密度的定量分析显示，饲养条件之间没有显著差异，这表明这种经化学鉴定的室旁核传入输入不受早期社会剥夺环境损伤的影响。室旁核对不同饲养条件明显缺乏易损性，这与在几个离散脑区观察到的神经病理学变化形成对比。
