Kitazawa Y, Suemori-Matsushita H, Yamamoto T, Kawase K
Department of Ophthalmology, Gifu University School of Medicine, Japan.
Ophthalmology. 1993 Nov;100(11):1624-8. doi: 10.1016/s0161-6420(93)31426-0.
The purpose of the study is to determine the optimum regimen of intraoperative administration of mitomycin as an adjunct to trabeculectomy.
Of 11 patients with primary open-angle glaucoma, 22 eyes that had not undergone any surgical intervention were included. In each patient, one eye was randomly allocated to a mitomycin 0.2-mg group and the fellow eye to a mitomycin 0.02-mg group. Mitomycin was applied for 5 minutes only once during trabeculectomy. The follow-up period was 6 to 17 months.
Eleven (100%) eyes in the 0.2-mg group and 7 (63.6%) in the 0.02-mg group achieved successful control of intraocular pressure with or without topical antiglaucoma medication. Transient hypotony maculopathy (18%) and cataract progression (18%) were noted in the 0.2-mg group exclusively. The incidence of other complications was similar between the two groups.
These data suggest that the most appropriate dose of mitomycin for primary surgery seems to be in between the two doses tested in the current study.
本研究旨在确定丝裂霉素术中给药作为小梁切除术辅助治疗的最佳方案。
纳入11例原发性开角型青光眼患者的22只未接受过任何手术干预的眼睛。在每位患者中，一只眼睛随机分配至丝裂霉素0.2毫克组，另一只眼睛分配至丝裂霉素0.02毫克组。丝裂霉素仅在小梁切除术中应用一次，持续5分钟。随访期为6至17个月。
0.2毫克组的11只（100%）眼睛以及0.02毫克组的7只（63.6%）眼睛在使用或未使用局部抗青光眼药物的情况下均成功控制了眼压。仅在0.2毫克组中观察到短暂性低眼压性黄斑病变（18%）和白内障进展（18%）。两组之间其他并发症的发生率相似。
这些数据表明，原发性手术中丝裂霉素的最合适剂量似乎介于本研究中测试的两种剂量之间。
