Seregard S
Division of Ophthalmic Pathology and Oncology, St Erik's Eye Hospital, Stockholm, Sweden.
Ophthalmology. 1993 Nov;100(11):1716-9. doi: 10.1016/s0161-6420(93)31412-0.
An 85-year-old woman had a bluish tumor medially on the margin of the left upper eyelid. Malignant melanoma of the conjunctiva was presumed; the lesion was excised and submitted for routine histopathologic examination. There are no signs of recurrence or metastatic disease after follow-up for 1 year.
Light microscopy with routine and histochemical stains were used for diagnosis. Immunohistochemical analysis included the use of a broad-spectrum "cocktail" of cytokeratin antibodies (AE1/AE3).
The features were those of a cystic cavity lined with apocrine epithelium in one part infiltrating the wall and consistent with an apocrine adenocarcinoma derived from a Moll gland cystadenoma.
Malignant Moll gland tumors are extremely uncommon but may be confused with conjunctival malignant melanoma or metastatic disease. The differential diagnosis to other sweat gland tumors such as eccrine adenocarcinoma and benign apocrine tumor or to sebaceous carcinoma can be difficult.
一名85岁女性左上眼睑边缘内侧有一个蓝色肿瘤。推测为结膜恶性黑色素瘤；切除该病变并进行常规组织病理学检查。随访1年后无复发或转移性疾病迹象。
采用常规和组织化学染色的光学显微镜进行诊断。免疫组织化学分析包括使用广谱细胞角蛋白抗体“鸡尾酒”（AE1/AE3）。
其特征为一个囊腔，部分内衬大汗腺上皮并浸润囊壁，符合源自睑板腺囊腺瘤的大汗腺癌。
恶性睑板腺肿瘤极为罕见，但可能与结膜恶性黑色素瘤或转移性疾病相混淆。与其他汗腺肿瘤如小汗腺腺癌、良性大汗腺肿瘤或皮脂腺癌进行鉴别诊断可能具有难度。
