Atlan H, Miquel J, Helmle L C, Dolkas C B
Mech Ageing Dev. 1976 Sep-Oct;5(5):371-87. doi: 10.1016/0047-6374(76)90035-x.
The data on mortality kinetics and decline in functions reported in the preceding article are used to calculate temperature coefficients for the aging process(es) in Drosophila. Different values are found, according to the model chosen to account for the mortality kinetics. The respective implications of three equally suitable models are discussed. Thus, organization parameters on two different levels can be identified: rates of changes assumed to occur at the elementary molecular level, and redundancy factors at a more integrated level. Their temperature coefficients are compared with those of protein denaturations and lipid peroxidation pigment accumulation. It is suggested that elementary molecular processes responsible for aging can indeed be protein denaturations, whereas the known lipid peroxidation pigment accumulation is more likely to be a secondary effect, resulting from a failure of the overall cellular organization at a more integrated, supramolecular, level.
上一篇文章中报道的关于果蝇衰老过程中死亡动力学和功能衰退的数据，用于计算衰老过程的温度系数。根据用于解释死亡动力学的模型不同，会得到不同的值。讨论了三种同样合适的模型各自的含义。因此，可以确定两个不同层面的组织参数：假定在基本分子层面发生变化的速率，以及在更综合层面的冗余因子。将它们的温度系数与蛋白质变性、脂质过氧化色素积累的温度系数进行了比较。研究表明，导致衰老的基本分子过程确实可能是蛋白质变性，而已知的脂质过氧化色素积累更可能是一种次级效应，是由更综合的超分子层面的整体细胞组织功能失效导致的。
