Piotrowska E, Piotrowski J, Grzeszczak W
Kliniki Chorób Wewnetrznych, Zabrzu.
Wiad Lek. 1993 May;46(9-10):327-31.
The studies of microsomal liver enzyme activity by means of a respiratory test with 14C-aminopyrine (ABT) were carried out in 20 patients with duodenal ulcer treated for eight weeks with famotidine. The respiratory test was performed before the introduction of treatment (group I), after four weeks of treatment (group II), and after eight weeks of treatment (group III). The mean value of the respiratory test before treatment was 5.32% of the dose/h. After four weeks of treatment with famotidine a significant decrease was found of the test value (x = 4.79% of the dose/h). An even stronger inhibitory action of famotidine on the microsomal system was shown after eight weeks of the treatment (x = 4.46% of the dose/h). These results evidence a depressive effect of famotidine on the activity of liver monooxygenases. In patients taking this drug, other drugs metabolised in the hepatocyte microsomal system should be used with high caution, as well as those which are known to be inhibitors of this system.
采用14C-氨基比林（ABT）呼吸试验对20例十二指肠溃疡患者进行了微粒体肝酶活性研究，这些患者接受法莫替丁治疗8周。呼吸试验在治疗开始前（I组）、治疗4周后（II组）和治疗8周后（III组）进行。治疗前呼吸试验的平均值为剂量/小时的5.32%。法莫替丁治疗4周后，试验值显著降低（x =剂量/小时的4.79%）。治疗8周后，法莫替丁对微粒体系统的抑制作用更强（x =剂量/小时的4.46%）。这些结果证明法莫替丁对肝单加氧酶活性有抑制作用。服用该药物的患者，在使用其他在肝细胞微粒体系统中代谢的药物时应格外谨慎，对于已知是该系统抑制剂的药物也应如此。
