Piotrowski J, Piotrowska E
Katedry i Kliniki Chorób Wewnetrznych i Zawodowych, Zabrzu.
Wiad Lek. 1993 Mar;46(5-6):178-82.
The functional status of hepatocytes was evaluated using the breathing test with 14C-aminopyrine in a group of patients with duodenal ulcer treated with cimetidine, and the reversibility of liver microsomal system activity changes was assessed at various time intervals after the completion of treatment with the above mentioned drug. Thirty patients with duodenal ulcer treated with cimetidine were examined: before the treatment (Ia), after one day of treatment (Ib), after four weeks of treatment (Ic), after eight weeks of treatment (Id), one week after completion of treatment (Ie), and four weeks after completion of treatment. A significant decrease was found of the value of the breathing test already after one day of treatment with cimetidine which was more pronounced after four and eight weeks of treatment. An impaired microsomal system activity was shown even one week after completion of the treatment with cimetidine. The obtained results indicate the necessity of caution when other drugs are administered to patients treated with cimetidine, and this refers particularly to drugs impairing liver function, or metabolized in this organ.
在一组接受西咪替丁治疗的十二指肠溃疡患者中，使用14C-氨基比林呼吸试验评估肝细胞的功能状态，并在上述药物治疗结束后的不同时间间隔评估肝微粒体系统活性变化的可逆性。对30例接受西咪替丁治疗的十二指肠溃疡患者进行了检查：治疗前（Ia）、治疗1天后（Ib）、治疗4周后（Ic）、治疗8周后（Id）、治疗结束1周后（Ie）以及治疗结束4周后。在用西咪替丁治疗1天后，呼吸试验值就已显著下降，在治疗4周和8周后更为明显。即使在西咪替丁治疗结束1周后，微粒体系统活性仍显示受损。所获结果表明，当给接受西咪替丁治疗的患者使用其他药物时需谨慎，这尤其适用于损害肝功能或在该器官代谢的药物。
