Barolin G S, Scholz H, Widhalm K, Hemmer W
MMW Munch Med Wochenschr. 1976 Sep 3;118(36):1117-20.
In an open, randomized anterospective, comparative study on encephalomalacias it was shown that with regard to the parameter of rehabilitation progress in the degree of paralysis, the patients treated with cortisone had a significantly better performance at the 5% level. The main point of attack of cortisone appears to be in the early phase of the insult (first 5 days). It seems unlikely that edema control is the only active principle. More probably this is an additional effect on cell metabolism. From these results it seems logical to continue to follow up the acute treatment of cerebral insult with cortisone and search for an optimal dosage and better confirmation.
在一项关于脑软化症的开放性、随机前瞻性对照研究中发现，就瘫痪程度的康复进展参数而言，接受可的松治疗的患者在5%的显著水平上表现明显更好。可的松的主要作用点似乎在损伤的早期阶段（前5天）。水肿控制似乎不太可能是唯一的有效原理。更有可能的是，这是对细胞代谢的一种附加作用。从这些结果来看，继续用可的松对脑损伤进行急性治疗并寻找最佳剂量和更好的证据似乎是合乎逻辑的。
