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疟疾的血清学诊断(作者译)

[Serodiagnosis of malaria (author's transl)].

作者信息

Mannweiler E, Mohr W, zum Felde I, Hinrichs A, Haas J

出版信息

MMW Munch Med Wochenschr. 1976 Sep 3;118(36):1139-44.

PMID:823409
Abstract

Homologous and heterologous malaria pathogens were used as antigens for the determination of malaria antibodies by indirect immunofluorescence. Homologous antibodies fell in the second half year, after successful treatment, down to the limit of demonstrability. In inhabitants of endemic malarial areas, who lived in the German Federal Republic, signs of a fall in antibodies could be observed after about 30 months. The predominance of particular malaria pathogens of the country of origin was recognizable in the antibody spectrum of these persons. Malaria antibody findings of three comparable groups of exposed persons under chemoprophylaxis ought to provide pointers to the parasitemias which had occurred and which were held responsible for the antibody production. Persons without chemoprophylaxis from malarial areas served as controls. The markedly deviating results of the antibody findings in the serum donors can only be explained by more seldom parasitemias in persons with adequate chemoprophylaxis.

摘要

使用同源和异源疟原虫病原体作为抗原,通过间接免疫荧光法测定疟疾抗体。成功治疗后,同源抗体在下半年降至可检测的下限。在居住在德意志联邦共和国的疟疾流行地区居民中,大约30个月后可观察到抗体下降的迹象。在这些人的抗体谱中可以识别出其原籍国特定疟原虫病原体的优势。三组接受化学预防的可比暴露人群的疟疾抗体检测结果应能为已发生的、导致抗体产生的寄生虫血症提供线索。来自疟疾地区未接受化学预防的人员作为对照。血清供体抗体检测结果明显不同,只能解释为接受充分化学预防的人员寄生虫血症较少。

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