Newens A J, Forster D P, Kay D W, Kirkup W, Bates D, Edwardson J
Division of Epidemiology and Public Health, University of Newcastle upon Tyne.
Psychol Med. 1993 Aug;23(3):631-44. doi: 10.1017/s0033291700025411.
Potential cases of presenile dementia of the Alzheimer type (PDAT) in the Northern Health Region (estimated population aged 45-64, 655,800) were ascertained for the years 1979-86 from in-patient ICD-9 codes and other sources. An algorithm was applied to the casenote information to distinguish between Alzheimer-type and other forms of dementia. A search of the NHS central register was made to establish date and place of death. Estimates were made for patients with missing case records. The point prevalence rate for PDAT was estimated as 34.6 per 100,000 with an annual incidence of 7.2 per 100,000 in the 45-64 age range. These rates are compared with those reported in other studies. Five-year survival following diagnosis for incident cases of PDAT was 64% with a longevity quotient (LQ), the percentage of expected time actually survived, of 69%. There was no evidence of a more malignant course in PDAT when compared with survival in older patients with dementia of the Alzheimer type (DAT) in other studies. Sixty-six per cent of deaths occurred in hospital, 19% at home and 15% in residential homes.
1979年至1986年期间，通过住院患者的国际疾病分类第九版（ICD - 9）编码及其他来源，在北部卫生区（估计45 - 64岁人口为655,800）确定了疑似早老性阿尔茨海默型痴呆（PDAT）病例。应用一种算法对病历信息进行分析，以区分阿尔茨海默型痴呆和其他形式的痴呆。对国民保健服务（NHS）中央登记册进行了检索，以确定死亡日期和地点。对缺失病例记录的患者进行了估算。PDAT的点患病率估计为每10万人中有34.6例，在45 - 64岁年龄范围内的年发病率为每10万人中有7.2例。将这些发病率与其他研究报告的发病率进行了比较。PDAT确诊病例的五年生存率为64%，长寿商数（LQ），即实际存活时间占预期时间的百分比，为69%。与其他研究中阿尔茨海默型痴呆（DAT）老年患者的生存率相比，没有证据表明PDAT的病程更恶性。66%的死亡发生在医院，19%在家中，15%在养老院。
