Sangla I, Blin O, Jouglard J, Cottin C, Berbis P, Pellissier J F, Serratrice G
Clinique des maladies du système nerveux et de l'appareil locomoteur, CHU Timone.
Rev Neurol (Paris). 1993;149(3):217-8.
A case of peripheral neuropathy following treatment with piroxicam is reported. The patient developed muscle pain and asymmetrical sensory distal neuropathy of the lower limbs a few months after the onset of the treatment. Piroxicam was withdrawn and full recovery was achieved within one year. The simultaneous appearance in the same patient of erythroderma with microvasculitis on nerve and skin biopsies suggests a common type III hypersensitivity mechanism in the pathogenesis of these two side-effects of piroxicam.
报告了1例服用吡罗昔康后出现周围神经病变的病例。该患者在治疗开始几个月后出现肌肉疼痛和双下肢不对称性感觉性远端神经病变。停用吡罗昔康后，1年内完全康复。同一患者在神经和皮肤活检中同时出现红皮病伴微血管炎，提示吡罗昔康这两种副作用的发病机制中存在共同的Ⅲ型超敏反应机制。
