Gamerith F, Zlabinger G J, Scherak O, Kolarz G, Schemper M, Heinzl H, Menzel J E
Institute of Immunology, University of Vienna, Austria.
Rheumatol Int. 1993;13(3):107-12. doi: 10.1007/BF00290297.
In the present study the ratio of antigen-bound anti-IgG-Fab antibodies (hidden aFab) to free aFab was found to be significantly increased in patients with adult onset rheumatoid arthritis (AORA) as compared to late onset rheumatoid arthritis (LORA). The overall amount of aFab was similar in both groups. The difference was only seen in seropositive patients. Within the seropositive AORA group, the aFab ratio was correlated with the duration and the stage of disease but not with the patients' age at investigation. This might reflect a higher affinity of anti-Fab antibodies and/or a greater diversity of the idiotypic repertoire in adult onset disease resulting in the formation of immune complexes, the stability of which might be enhanced further by the presence of rheumatoid factors. Although a pathophysiological involvement of aFab cannot be concluded from our observations, it is conceivable that different immunoregulatory mechanisms could be operative in RA with onset at different ages.
在本研究中，发现与晚发型类风湿关节炎（LORA）相比，成人起病型类风湿关节炎（AORA）患者中抗原结合抗IgG - Fab抗体（隐蔽性aFab）与游离aFab的比例显著升高。两组中aFab的总量相似。差异仅在血清阳性患者中可见。在血清阳性的AORA组中，aFab比例与疾病持续时间和阶段相关，但与研究时患者的年龄无关。这可能反映了成人起病型疾病中抗Fab抗体具有更高的亲和力和/或独特型库的多样性更大，从而导致免疫复合物的形成，类风湿因子的存在可能会进一步增强其稳定性。虽然从我们的观察结果不能得出aFab的病理生理参与情况，但可以想象，不同年龄起病的类风湿关节炎可能存在不同的免疫调节机制。
