Matsuda S, Oka S, Honda M, Takebe Y, Takemori T
AIDS Research Center, National Institute of Health, Tokyo, Japan.
Scand J Immunol. 1993 Nov;38(5):428-34. doi: 10.1111/j.1365-3083.1993.tb02584.x.
IgA antibodies were analysed in sera and saliva from 40 HIV-1 seropositive individuals. The level of total IgA in serum was elevated according to the progress of the disease. IgA antibodies against p24 and gp160 were detected in the asymptomatic phase of infection. However, they declined in the symptomatic phases in contrast with IgG antibodies. Interestingly, three patients in the symptomatic phase who showed high levels of IgA antibodies were all in relatively good clinical condition. The IgG and IgA antibodies in saliva declined in the symptomatic phase. The level of IgG anti-p24 antibodies in saliva correlated with that in serum, suggesting that IgG anti-p24 antibodies in saliva originated from those in the serum. These results indicate that IgA antibodies are regulated independently from IgG antibodies and that the mucosal immune system is impaired early in the symptomatic phase of HIV infection, which starts with mucosal impairment. Detection of IgA antibodies may be useful for prognosis of the disease in HIV-infected individuals. The results indicate also that treatment for the impaired IgA mucosal immune system should be taken into consideration.
对40名HIV-1血清阳性个体的血清和唾液中的IgA抗体进行了分析。血清中总IgA水平随疾病进展而升高。在感染的无症状期检测到针对p24和gp160的IgA抗体。然而，与IgG抗体相比，它们在症状期下降。有趣的是，症状期表现出高水平IgA抗体的三名患者临床状况相对良好。唾液中的IgG和IgA抗体在症状期下降。唾液中IgG抗p24抗体水平与血清中相关，表明唾液中IgG抗p24抗体源自血清中的抗体。这些结果表明，IgA抗体独立于IgG抗体受到调节，并且在HIV感染的症状期早期黏膜免疫系统受损，该症状期始于黏膜损伤。检测IgA抗体可能有助于预测HIV感染个体的疾病预后。结果还表明，应考虑对受损的IgA黏膜免疫系统进行治疗。
