Rees D, Soderlund N, Cronje R, Song E, Kielkowski D, Myers J
National Centre for Occupational Health, Johannesburg, South Africa.
Scand J Work Environ Health. 1993 Aug;19(4):236-44. doi: 10.5271/sjweh.1478.
Liver enzyme activity was examined in 89 South African paint makers currently exposed to a mixture of organic solvents at fairly low levels. However, the duration of exposure was substantial for many. Fifty-eight workers (65%) had at least one enzyme value above the upper reference limit. Gamma glutamyl transferase (gamma GT) activity was elevated in 46% of the workers and aspartate aminotransferase (ASAT) in 52%. In a comparison between workers with high and low solvent exposure, the gamma GT and ASAT values were higher in the most exposed group (eg, gamma GT mean 108 versus 69 U.l-1, P > 0.05). Adjustment for confounding by alcohol consumption and body mass index eliminated the differences due to exposure. It was concluded that the measures of liver injury used did not demonstrate solvent-induced hepatic damage but that excessive alcohol consumption was an important factor.
对89名目前暴露于低水平有机溶剂混合物的南非油漆工进行了肝酶活性检测。然而，许多人的暴露时间相当长。58名工人（65%）至少有一项酶值高于参考上限。46%的工人γ-谷氨酰转移酶（γ-GT）活性升高，52%的工人天冬氨酸转氨酶（ASAT）活性升高。在高溶剂暴露组和低溶剂暴露组工人的比较中，暴露程度最高的组γ-GT和ASAT值更高（例如，γ-GT平均值为108对69 U·l⁻¹，P>0.05）。对饮酒和体重指数造成的混杂因素进行调整后，消除了因暴露导致的差异。得出的结论是，所采用的肝损伤指标未显示出溶剂诱导的肝损伤，但过量饮酒是一个重要因素。
