受体酪氨酸激酶如何激活Ras。 - Suppr

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How receptor tyrosine kinases activate Ras.

作者信息

Schlessinger J

机构信息

New York University Medical Center, Department of Pharmacology, NY 10016.

出版信息

Trends Biochem Sci. 1993 Aug;18(8):273-5. doi: 10.1016/0968-0004(93)90031-h.

DOI:10.1016/0968-0004(93)90031-h

PMID:8236435

Abstract

摘要

相似文献

How receptor tyrosine kinases activate Ras.

Trends Biochem Sci. 1993 Aug;18(8):273-5. doi: 10.1016/0968-0004(93)90031-h.

Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?

Biochem J. 2003 Dec 15;376(Pt 3):e9-10. doi: 10.1042/BJ20031745.

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.

Nature. 1993 May 6;363(6424):45-51. doi: 10.1038/363045a0.

The role of p21ras in receptor tyrosine kinase signalling.

Biochim Biophys Acta. 1994 Dec 30;1198(2-3):131-47. doi: 10.1016/0304-419x(94)90010-8.

A quantitative model of developmental RTK signaling.

Dev Biol. 2018 Oct 1;442(1):80-86. doi: 10.1016/j.ydbio.2018.07.012. Epub 2018 Jul 17.

Ras blooms on sterile ground.

Nature. 1994 Jun 2;369(6479):361-2. doi: 10.1038/369361a0.

The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.

Cell. 1995 Apr 7;81(1):63-71. doi: 10.1016/0092-8674(95)90371-2.

Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.

Oncogene. 1995 Dec 7;11(11):2207-14.

Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.

Genes Cells. 2006 Feb;11(2):143-51. doi: 10.1111/j.1365-2443.2006.00926.x.

Regulators and effectors of ras proteins.

Annu Rev Cell Biol. 1991;7:601-32. doi: 10.1146/annurev.cb.07.110191.003125.

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PLoS One. 2011;6(9):e24421. doi: 10.1371/journal.pone.0024421. Epub 2011 Sep 8.

The heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signal.

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Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives.

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Calcineurin inhibitors activate the proto-oncogene Ras and promote protumorigenic signals in renal cancer cells.

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Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.

J Cell Sci. 2007 Oct 1;120(Pt 19):3465-74. doi: 10.1242/jcs.005942. Epub 2007 Sep 12.

MAP kinase pathways: the first twenty years.

Biochim Biophys Acta. 2007 Aug;1773(8):1150-60. doi: 10.1016/j.bbamcr.2006.11.006. Epub 2006 Nov 15.

The role of PDGF in radiation oncology.

Radiat Oncol. 2007 Jan 11;2:5. doi: 10.1186/1748-717X-2-5.

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How receptor tyrosine kinases activate Ras.

作者信息

Schlessinger J

机构信息

New York University Medical Center, Department of Pharmacology, NY 10016.

出版信息

Trends Biochem Sci. 1993 Aug;18(8):273-5. doi: 10.1016/0968-0004(93)90031-h.

DOI:10.1016/0968-0004(93)90031-h

PMID:8236435

Abstract

摘要

相似文献

How receptor tyrosine kinases activate Ras.

Trends Biochem Sci. 1993 Aug;18(8):273-5. doi: 10.1016/0968-0004(93)90031-h.

Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?

Biochem J. 2003 Dec 15;376(Pt 3):e9-10. doi: 10.1042/BJ20031745.

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.

Nature. 1993 May 6;363(6424):45-51. doi: 10.1038/363045a0.

The role of p21ras in receptor tyrosine kinase signalling.

Biochim Biophys Acta. 1994 Dec 30;1198(2-3):131-47. doi: 10.1016/0304-419x(94)90010-8.

A quantitative model of developmental RTK signaling.

Dev Biol. 2018 Oct 1;442(1):80-86. doi: 10.1016/j.ydbio.2018.07.012. Epub 2018 Jul 17.

Ras blooms on sterile ground.

Nature. 1994 Jun 2;369(6479):361-2. doi: 10.1038/369361a0.

The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.

Cell. 1995 Apr 7;81(1):63-71. doi: 10.1016/0092-8674(95)90371-2.

Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.

Oncogene. 1995 Dec 7;11(11):2207-14.

Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.

Genes Cells. 2006 Feb;11(2):143-51. doi: 10.1111/j.1365-2443.2006.00926.x.

Regulators and effectors of ras proteins.

Annu Rev Cell Biol. 1991;7:601-32. doi: 10.1146/annurev.cb.07.110191.003125.

引用本文的文献

CEBPB regulates ERK1/2 activity through SOS1 and contributes to ovarian cancer progression.

Med Oncol. 2025 Jun 7;42(7):242. doi: 10.1007/s12032-025-02794-2.

NRas activity is regulated by dynamic interactions with nanoscale signaling clusters at the plasma membrane.

iScience. 2022 Oct 9;25(11):105282. doi: 10.1016/j.isci.2022.105282. eCollection 2022 Nov 18.

Temperature and urea have opposing impacts on polyproline II conformational bias.

Biochemistry. 2013 Feb 5;52(5):949-58. doi: 10.1021/bi301435p. Epub 2013 Jan 27.

G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy.

PLoS One. 2011;6(9):e24421. doi: 10.1371/journal.pone.0024421. Epub 2011 Sep 8.

The heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signal.

J Biol Chem. 2011 Sep 23;286(38):33580-90. doi: 10.1074/jbc.M111.248401. Epub 2011 Jul 31.

Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives.

Genes Cancer. 2011 Mar;2(3):298-305. doi: 10.1177/1947601911408078.

Calcineurin inhibitors activate the proto-oncogene Ras and promote protumorigenic signals in renal cancer cells.

Cancer Res. 2009 Dec 1;69(23):8902-9. doi: 10.1158/0008-5472.CAN-09-1404. Epub 2009 Nov 10.

Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.

J Cell Sci. 2007 Oct 1;120(Pt 19):3465-74. doi: 10.1242/jcs.005942. Epub 2007 Sep 12.

MAP kinase pathways: the first twenty years.

Biochim Biophys Acta. 2007 Aug;1773(8):1150-60. doi: 10.1016/j.bbamcr.2006.11.006. Epub 2006 Nov 15.

The role of PDGF in radiation oncology.

Radiat Oncol. 2007 Jan 11;2:5. doi: 10.1186/1748-717X-2-5.