Bozhko H Kh
Ukr Biokhim Zh (1978). 1993 Mar-Apr;65(2):95-9.
The composition and incorporation of labelled amino acids in electrophoretic fractions of soluble proteins of the liver, brain, heart, kidneys and adrenal tissues of guinea pigs have been studied after 3 months of hypercholesterolemia. Similar quantitative changes in all the investigated tissues have been discovered as manifested by the increase of high-molecular proteins concentration and decrease of low-molecular polypeptides. The decrease of specific radioactivity of total proteins and some electrophoretic fractions has been observed under hypercholesterolemia. Only one of the fractions in the adrenals was characterized by the increase of the label incorporation level. The obtained results indicate that the long-term hypercholesterolemia is accompanied by quantitative redistribution of soluble proteins of the tissues and by suppression of their synthesis.
在豚鼠出现高胆固醇血症3个月后，对其肝脏、大脑、心脏、肾脏和肾上腺组织可溶性蛋白质电泳组分中标记氨基酸的组成和掺入情况进行了研究。在所有研究的组织中均发现了类似的定量变化，表现为高分子蛋白质浓度增加，低分子多肽减少。在高胆固醇血症情况下，观察到总蛋白质和一些电泳组分的比放射性降低。肾上腺中只有一个组分的标记掺入水平增加。所得结果表明，长期高胆固醇血症伴随着组织可溶性蛋白质的定量重新分布及其合成的抑制。
