Bozhko G Kh, Chursina V S, Kulabukhov V M
Ukr Biokhim Zh (1978). 1990 Jan-Feb;62(1):30-4.
The synthesis of soluble liver proteins and amino acid incorporation into blood serum proteins were studied in guinea pigs which were daily administered ethanol and cholesterol during 3 months. 9 fractions obtained by electrophoresis in polyacrylamide gel were analyzed. It has been found that ethanol and cholesterol in the liver suppress the synthesis of 4 out of 9 recorded protein fractions. In the serum the ethanol effect against a background of the cholesterol administration is characterized by a sharp decrease of specific radioactivity of albumins while the quantity of the protein fraction is unchanged. These results together with the data available in literature on the ethanol suppression of proteolysis suppose that the joint effect of ethanol and cholesterol is accompanied by a decrease in the blood serum albumin decomposition.
对豚鼠进行了研究，这些豚鼠在3个月内每日给予乙醇和胆固醇，观察其肝脏中可溶性蛋白质的合成以及氨基酸掺入血清蛋白的情况。对通过聚丙烯酰胺凝胶电泳获得的9个组分进行了分析。已发现肝脏中的乙醇和胆固醇会抑制所记录的9种蛋白质组分中的4种的合成。在血清中，在给予胆固醇的背景下，乙醇的作用表现为白蛋白的比放射性急剧下降，而蛋白质组分的量不变。这些结果连同文献中关于乙醇抑制蛋白水解的数据表明，乙醇和胆固醇的联合作用伴随着血清白蛋白分解的减少。
