猪自然产生α干扰素的细胞频率及单个细胞干扰素产量随年龄增长而增加。
Age-related increase of porcine natural interferon alpha producing cell frequency and of interferon yield per cell.
作者信息
Nowacki W, Cederblad B, Renard C, La Bonnardière C, Charley B
机构信息
Laboratoire de Virologie et Immunologie Moléculaires, INRA, Jouy en Josas, France.
出版信息
Vet Immunol Immunopathol. 1993 Jul;37(2):113-22. doi: 10.1016/0165-2427(93)90059-d.
Abstract
Porcine blood mononuclear cells (PBMC) were shown to secrete interferon alpha (IFN-alpha) after induction by a coronavirus, the transmissible gastroenteritis virus (TGEV). IFN-alpha producing cells, referred to as natural interferon alpha producing (NIP) cells, were detected by an ELISPOT assay using anti-porcine IFN-alpha monoclonal antibodies. The frequency of NIP cells among blood cells is low, at most 40-110 per 10(5) PBMC and each NIP cell was found to produce several units of IFN. We have shown that NIP cell frequency and IFN yield per cell gradually increased with the age of the donor animals, from the neonatal period to the adult age, with a significant increase around puberty. Our present results also indicate that NIP cells may be influenced by physiological and genetic factors; thus (1) NIP cell frequency and IFN yield per cell were decreased during lactation; (2) Chinese (Meishan) pigs were found to have higher NIP cell frequency and IFN yield per cell than European (Large White) animals.
摘要
猪血液单核细胞（PBMC）在受到冠状病毒——传染性胃肠炎病毒（TGEV）诱导后，被证明能分泌α干扰素（IFN-α）。通过使用抗猪IFN-α单克隆抗体的ELISPOT分析检测到产生IFN-α的细胞，即所谓的天然α干扰素产生（NIP）细胞。血细胞中NIP细胞的频率较低，每10⁵个PBMC中最多有40 - 110个，并且发现每个NIP细胞能产生几个单位的IFN。我们已经表明，从新生期到成年期，随着供体动物年龄的增长，NIP细胞频率和每个细胞的IFN产量逐渐增加，在青春期前后有显著增加。我们目前的结果还表明，NIP细胞可能受到生理和遗传因素的影响；因此（1）在哺乳期，NIP细胞频率和每个细胞的IFN产量会降低；（2）发现中国（梅山）猪比欧洲（大白）猪具有更高的NIP细胞频率和每个细胞的IFN产量。
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