去甲斑蝥酸钠白蛋白微球的研究
[Study on sodium norcantharidate albumin microspheres].
作者信息
Cheng Y H, Liao G T, Hou S X, Li L
机构信息
School of Pharmacy, West China University of Medical Sciences, Chengdu.
出版信息
Yao Xue Xue Bao. 1993;28(5):384-8.
In this paper sodium norcantharidate (Na2NC) was chosen as model drug and sodium norcantharidate albumin microspheres (Na2NC AM) was prepared by an optimal procedure. The embedding nature, appearance, morphology, size and size distribution, release characteristics in vitro, freeze-drying, 60Co radiosterilization and stability of Na2NC AM were tested. The results showed that the mean size was 0.43 +/- 0.12 micron, embedding concentration was 20.34-26.75 micrograms/mg, embedding ratio was 21.9-26.4%, release characteristics in vitro was in accord with Higuchi equation. Freeze-drying and 60Co radiosterilization showed no influence on Na2NC AM. The stability of Na2NC AM was good after 3 months storage.
本文选用去甲斑蝥酸钠（Na2NC）作为模型药物，通过优化工艺制备了去甲斑蝥酸钠白蛋白微球（Na2NC AM）。对Na2NC AM的包封性质、外观、形态、粒径及粒径分布、体外释放特性、冻干、60Co辐射灭菌和稳定性进行了考察。结果表明，平均粒径为0.43±0.12μm，包封浓度为20.34 - 26.75μg/mg，包封率为21.9 - 26.4%，体外释放特性符合Higuchi方程。冻干和60Co辐射灭菌对Na2NC AM无影响。Na2NC AM在储存3个月后稳定性良好。
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