Singh K, Viegas O A, Ratnam S S
Department of Obstetrics and Gynecology, National University Hospital, Singapore.
Adv Contracept. 1993 Sep;9(3):241-50. doi: 10.1007/BF01982947.
Women using the Norplant-2 rod system in Singapore have been shown to have a change in their hemostatic function. There is a decrease in vitamin K dependent factors II, VII and a tendency toward lowered fibrinolytic activity after use of Norplant-2 rods. There was also an increase in platelet number and accelerated-platelet aggregation. These changes are similar to those seen with the Norplant six-capsule system and it would appear that both systems do not activate the coagulation system or enhance a state of hypercoagulation. On removal of the Norplant-2 rods at the end of 5 years, the significant changes seen in hemoglobin function observed with Norplant-2 rod use remained.
在新加坡，使用诺普兰二代（Norplant-2）皮下埋植避孕系统的女性已被证明其止血功能发生了变化。使用诺普兰二代皮下埋植剂后，维生素K依赖因子II、VII减少，纤溶活性有降低趋势。血小板数量也有所增加，血小板聚集加速。这些变化与诺普兰六胶囊系统所见相似，似乎两种系统均未激活凝血系统或增强高凝状态。在5年末取出诺普兰二代皮下埋植剂后，使用诺普兰二代皮下埋植剂时观察到的血红蛋白功能的显著变化依然存在。
