Platz-Christensen J J, Mattsby-Baltzer I, Thomsen P, Wiqvist N
Department of Obstetrics and Gynecology, University of Göteborg, Sweden.
Am J Obstet Gynecol. 1993 Nov;169(5):1161-6. doi: 10.1016/0002-9378(93)90274-m.
The purpose of our study was to determine the concentrations of endotoxin and interleukin-1 alpha in the cervical mucus and vaginal fluid of pregnant women who either did or did not have bacterial vaginosis.
Samples of cervical mucus and vaginal fluid were collected from women in early pregnancy who had signs of bacterial vaginosis and from healthy control subjects. The samples were analyzed for the concentrations of endotoxin and interleukin-1 alpha. In addition, wet mounts were examined for signs of inflammation indicated by increased numbers of leukocytes.
Both endotoxin and interleukin-1 alpha occurred in much higher concentrations (p < 0.0001, p < 0.0002) in both the cervical mucus and the vaginal fluid of women with signs of bacterial vaginosis than they did in healthy control subjects. A correlation was found between the interleukin-1 alpha concentrations in the vaginal fluid and the number of leukocytes as judged by a semi-quantitative evaluation of wet mounts (p = 0.0365). The concentrations of endotoxin correlated with those of interleukin-1 alpha in both fluids (vaginal fluid, p < 0.01; cervical mucus, p < 0.01).
Our study shows that concentrations of endotoxin and interleukin-1 alpha in cervical mucus and vaginal fluid of women in early pregnancy who have bacterial vaginosis are significantly higher than the corresponding levels in control subjects.
我们研究的目的是确定患有或未患有细菌性阴道病的孕妇宫颈黏液和阴道分泌物中内毒素和白细胞介素 -1α 的浓度。
从有细菌性阴道病体征的早孕女性和健康对照者中采集宫颈黏液和阴道分泌物样本。对样本进行内毒素和白细胞介素 -1α 浓度分析。此外，检查湿片以观察白细胞数量增加所表明的炎症迹象。
有细菌性阴道病体征的女性，其宫颈黏液和阴道分泌物中的内毒素和白细胞介素 -1α 浓度均显著高于健康对照者（p < 0.0001，p < 0.0002）。通过湿片的半定量评估判断，发现阴道分泌物中白细胞介素 -1α 浓度与白细胞数量之间存在相关性（p = 0.0365）。两种分泌物中内毒素浓度均与白细胞介素 -1α 浓度相关（阴道分泌物，p < 0.01；宫颈黏液，p < 0.01）。
我们的研究表明，患有细菌性阴道病的早孕女性宫颈黏液和阴道分泌物中内毒素和白细胞介素 -1α 的浓度显著高于对照者的相应水平。
