Lahita R G, Rivkin E, Cavanagh I, Romano P
Saint Luke's Roosevelt Medical Center, Columbia University, New York, New York 10019.
Arthritis Rheum. 1993 Nov;36(11):1566-74. doi: 10.1002/art.1780361111.
To determine if there is an association between low levels of high-density lipoprotein cholesterol (HDL), apolipoprotein A1 (Apo A1), total cholesterol, and anticardiolipin antibody (aCL) in patients with systemic lupus erythematosus (SLE) who are not taking corticosteroids.
We studied 75 outpatients with documented SLE who were attending our hospital clinics: 57 were aCL positive and 18 were aCL negative. Both IgG and IgM aCL levels were determined by enzyme-linked immunosorbent assay. Lipid fractions (total cholesterol, HDL, low-density lipoprotein, very-low-density lipoprotein, and triglycerides) were determined by standard enzymatic techniques. Apo A1 and Apo B levels were determined by nephelometry.
Patients with SLE who were IgG aCL+ had low levels of serum cholesterol (mean +/- SD 173.6 +/- 34.6 mg/dl) and HDL (43.9 +/- 16.3 mg/dl) compared with aCL- SLE patients, normal donors, and patients with other diseases. Apo A1 levels were also low in the aCL+ group (95.5 +/- 50.9 mg/dl) compared with the aCL- group (152.7 +/- 32.6 mg/dl). There was no association of total cholesterol level or aCL titer with clinical activity.
These data indicate that in SLE patients, there is an association between antibody against the phospholipid cardiolipin and low levels of cholesterol, HDL, and Apo A1.
确定在未服用皮质类固醇的系统性红斑狼疮（SLE）患者中，高密度脂蛋白胆固醇（HDL）、载脂蛋白A1（Apo A1）、总胆固醇水平低与抗心磷脂抗体（aCL）之间是否存在关联。
我们研究了75名在我院门诊就诊的确诊SLE门诊患者：57名aCL阳性，18名aCL阴性。通过酶联免疫吸附测定法测定IgG和IgM aCL水平。采用标准酶法测定血脂成分（总胆固醇、HDL、低密度脂蛋白、极低密度脂蛋白和甘油三酯）。通过散射比浊法测定Apo A1和Apo B水平。
与aCL阴性的SLE患者、正常供体及其他疾病患者相比，IgG aCL阳性的SLE患者血清胆固醇水平低（均值±标准差173.6±34.6mg/dl），HDL水平低（43.9±16.3mg/dl）。与aCL阴性组（152.7±32.6mg/dl）相比，aCL阳性组的Apo A1水平也低（95.5±50.9mg/dl）。总胆固醇水平或aCL滴度与临床活动无关联。
这些数据表明，在SLE患者中，抗磷脂心磷脂抗体与胆固醇、HDL和Apo A1水平低之间存在关联。
