Liou H H, Wang C R, Chen C J, Chen R C, Chuang C Y, Chiang I P, Tsai M C
Department of Neurology, National Taiwan University Hospital, Taipei.
Lupus. 1996 Aug;5(4):307-12. doi: 10.1177/096120339600500412.
To examine the association between anticardiolipin (aCL) antibodies and epilepsy, we investigated the serum titers of aCL antibodies in a total 252 systemic lupus erythematosus (SLE) patients recruited in a prospective study. Twenty-one cases with epilepsy which were not attributable to any causes other than SLE were identified after being followed-up for five years. The clinical manifestations were recorded and blood samples were tested for the presence of aCL antibodies (IgG, IgM and IgA isotypes). Among 21 patients with epilepsy, 12 (57.1%), 2 (9.5%) and 2 (9.5%), respectively, had elevated baseline serum levels of IgG, IgM and IgA aCL antibodies. There was a dose-response relationship between risk of seizure and the baseline serum level of aCL antibodies (P < 0.01). The odds ratio of developing seizure were 3.7 for those who had a high level of aCL antibodies compared with those without a detectable level of aCL antibodies as the referent. Our results indicate that epilepsy as a primary neuropsychiatric event among lupus patients is associated with a high titer of aCL antibodies.
为了研究抗心磷脂（aCL）抗体与癫痫之间的关联，我们在一项前瞻性研究中调查了总共252例系统性红斑狼疮（SLE）患者的血清aCL抗体滴度。经过五年的随访，确定了21例癫痫病例，这些病例除SLE外无其他病因。记录了临床表现，并检测血样中aCL抗体（IgG、IgM和IgA亚型）的存在情况。在21例癫痫患者中，分别有12例（57.1%）、2例（9.5%）和2例（9.5%）的IgG、IgM和IgA aCL抗体基线血清水平升高。癫痫发作风险与aCL抗体基线血清水平之间存在剂量反应关系（P<0.01）。与无可检测水平aCL抗体的患者作为对照相比，aCL抗体水平高的患者发生癫痫发作的比值比为3.7。我们的结果表明，癫痫作为狼疮患者的原发性神经精神事件与高滴度的aCL抗体有关。
