Adkins R T, Van Hooydonk J E, Bressman P L, Growdon J H, Bolen P R, Varin J C, Thompson B R
PharmaThera Inc, Nashville, Tennessee.
South Med J. 1993 Feb;86(2):157-64.
We evaluated a program for prevention of preterm birth involving early detection and aggressive intervention with subcutaneous terbutaline pump therapy in a high-risk, private patient population. Risk factor screening, frequent cervical examinations, and intensive patient education were used to detect preterm labor before it progressed to an advanced stage. Home terbutaline pump therapy was prescribed for patients with uterine contractions associated with progressive cervical change, after stabilization with IV magnesium sulfate. In this study of 51 patients, home terbutaline pump therapy was successful in 98% of the cases, prolonging pregnancy an average of 6.6 weeks. Mean gestational age at delivery was 37 +/- 1.4 weeks, and infant birth weight averaged 3 kg. Only 22% of infants required admission to the neonatal intensive care unit, with a mean length of stay of 7.25 days. Population factors in this compliant, well-educated patient group may have contributed to the positive outcomes achieved.
我们评估了一项预防早产的项目，该项目在一个高风险的私立患者群体中，通过皮下特布他林泵疗法进行早期检测和积极干预。通过风险因素筛查、频繁的宫颈检查以及强化患者教育，在早产进展到晚期之前检测早产。对于在静脉注射硫酸镁稳定病情后出现与宫颈逐渐变化相关的子宫收缩的患者，开具了家庭特布他林泵疗法。在这项对51名患者的研究中，家庭特布他林泵疗法在98%的病例中取得成功，平均延长妊娠6.6周。分娩时的平均孕周为37±1.4周，婴儿出生体重平均为3千克。只有22%的婴儿需要入住新生儿重症监护病房，平均住院时间为7.25天。这个依从性好、受过良好教育的患者群体中的人口因素可能促成了所取得的积极结果。
