Department of Chemistry at the University of Illinois Urbana-Champaign, Urbana, IL, USA; Carl R. Woese Institute for Genomic Biology at University of Illinois Urbana-Champaign, Urbana, IL, USA.
Department of Chemistry at the University of Illinois Urbana-Champaign, Urbana, IL, USA; Carl R. Woese Institute for Genomic Biology at University of Illinois Urbana-Champaign, Urbana, IL, USA.
Trends Genet. 2024 Nov;40(11):950-968. doi: 10.1016/j.tig.2024.08.002. Epub 2024 Aug 31.
Lasso peptides are a large and sequence-diverse class of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products characterized by their slip knot-like shape. These unique, highly stable peptides are produced by bacteria for various purposes. Their stability and sequence diversity make them a potentially useful scaffold for biomedically relevant folded peptides. However, many questions remain about lasso peptide biosynthesis, ecological function, and diversification potential for biomedical and agricultural applications. This review discusses new insights and open questions about lasso peptide biosynthesis and biological function. The role that genome mining has played in the development of new methodologies for discovering and diversifying lasso peptides is also discussed.
套索肽是一类由核糖体合成并经翻译后修饰的大型、序列多样的肽（RiPP）天然产物，其特征为滑结样形状。这些独特的、高度稳定的肽由细菌产生，用于各种目的。它们的稳定性和序列多样性使它们成为生物医学相关折叠肽的潜在有用支架。然而，关于套索肽生物合成、生态功能以及在生物医学和农业应用中的多样化潜力，仍有许多问题尚待解决。本综述讨论了套索肽生物合成和生物学功能方面的新见解和未解决的问题。还讨论了基因组挖掘在发现和多样化套索肽的新方法发展中所起的作用。
