Boujon C E, Bestetti G E, Meier H P, Straub R, Junker U, Rossi G L
Institute of Animal Pathology, University of Berne, Switzerland.
J Comp Pathol. 1993 Aug;109(2):163-78. doi: 10.1016/s0021-9975(08)80260-5.
Clinico-pathological correlations in horses with pituitary adenomas are poorly understood. This paper describes the functional and morphological features of five cases of equine pituitary adenoma and of a case of multinodular pituitary hyperplasia. New findings reported include immunoreactivity for beta-lipotropin (beta-LPH), beta-melanocyte-stimulating hormone (beta-MSH), gamma 3-MSH, prolactin (PRL), and follicle-stimulating hormone (FSH) in neoplastic cells of the pituitary adenoma; and, in the multinodular hyperplasia, beta-LPH, beta-endorphin (beta-END), alpha-MSH, beta-MSH, gamma 3-MSH and FSH immunoreactivity. It is suggested that the equine pituitary syndrome does not correspond to human Cushing's disease, as generally accepted, but is related to the overproduction of several pro-opiomelanocortin (POMC)-derived peptides by the cells of the tumour or hyperplastic nodules.
马垂体腺瘤的临床病理相关性尚不清楚。本文描述了5例马垂体腺瘤及1例多结节性垂体增生的功能和形态学特征。报告的新发现包括垂体腺瘤肿瘤细胞中β-促脂素（β-LPH）、β-黑素细胞刺激素（β-MSH）、γ3-MSH、催乳素（PRL）和促卵泡激素（FSH）的免疫反应性；以及在多结节性增生中，β-LPH、β-内啡肽（β-END）、α-MSH、β-MSH、γ3-MSH和FSH的免疫反应性。研究表明，马垂体综合征并不像普遍认为的那样与人类库欣病相对应，而是与肿瘤或增生性结节细胞过度产生几种源自阿片-黑素细胞皮质素原（POMC）的肽有关。
