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[患有肌病患者胸腺中的肌样细胞]

[Myoid cells in the thymus of patients with myopathy].

作者信息

Valikova T A, Gnezditskaia E V, Beletskaia L V, Shiianevskiĭ A Ia, Pekarskiĭ V V

出版信息

Biull Eksp Biol Med. 1982 Jan;93(1):104-6.

PMID:7039718
Abstract

Immunofluorescence was used to demonstrate that in progressive muscular dystrophy, myoid cells in the patients' thymus undergo profound changes which affect the processes of their formation, differentiation and maturation. Pronounced changes in the myoid cells were disclosed in two forms of myopathy. These changes lie in the increased number of myoid antigens in Erb's myopathy, whereas in Duchenne's myopathy, they manifest in the diminution of the number of myoid antigens in the internal environment of the thymus. It is suggested that the differences in the pattern of changes in the myoid cells, apart from other factors, apparently govern the peculiarity of the pathological process in the two forms of muscular dystrophy.

摘要

免疫荧光法被用于证明,在进行性肌营养不良中,患者胸腺中的类肌细胞会发生深刻变化,这些变化会影响其形成、分化和成熟过程。在两种肌病中都发现了类肌细胞的明显变化。这些变化在埃布氏肌病中表现为类肌抗原数量增加,而在杜兴氏肌病中,则表现为胸腺内环境中类肌抗原数量减少。有人认为,除其他因素外,类肌细胞变化模式的差异显然决定了这两种肌营养不良病理过程的特殊性。

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