Juchau M R, Bond J A, Benditt E P
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3723-5. doi: 10.1073/pnas.73.10.3723.
Aryl 4-monooxygenase [aniline, reduced-flavoprotein:oxygen oxidoreductase (4-hydroxylating); EC 1.14.14.1] activity was searched for and found in homogenates of aorta walls from rabbits, rhesus monkeys, and humans. Specific activities were comparable to activities observed in several other extrahepatic tissues of rabbits and monkeys and in epidermal tissues from mice, but were one to two orders of magnitude lower than those observed in corresponding preparations of hepatic tissues. Cytochrome P-450 also could be detected in low concentrations in microsomal fractions of aortic wall homogenates. The monooxygenase activity found in the aorta could play a significant role in the etiology and pathogenesis of atherosclerosis in humans by catalyzing the conversion of environmental promutagens to mutagenic initiators and/or cytotoxic factors, thus leading to development of benign, smooth muscle tumors of the inner lining of artery walls.
对芳基4-单加氧酶[苯胺，还原型黄素蛋白：氧氧化还原酶（4-羟化）；EC 1.14.14.1]活性进行了检测，并在兔、恒河猴和人的主动脉壁匀浆中发现了该活性。比活性与在兔和猴的其他几种肝外组织以及小鼠表皮组织中观察到的活性相当，但比在相应肝组织制剂中观察到的活性低一到两个数量级。在主动脉壁匀浆的微粒体部分也能检测到低浓度的细胞色素P-450。在主动脉中发现的单加氧酶活性可能通过催化环境前诱变剂转化为诱变引发剂和/或细胞毒性因子，从而在人类动脉粥样硬化的病因学和发病机制中发挥重要作用，进而导致动脉壁内层良性平滑肌肿瘤的发生。
